557-36-8Relevant articles and documents
Iron-Catalyzed Oxyalkylation of Terminal Alkynes with Alkyl Iodides
Deng, Weili,Ye, Changqing,Li, Yajun,Li, Daliang,Bao, Hongli
supporting information, p. 261 - 265 (2019/01/10)
A general oxyalkylation of terminal alkynes enabled by iron catalysis has been developed. Primary and secondary alkyl iodides acted as the alkylating reagents and afforded a range of α-alkylated ketones under mild reaction conditions. Acetyl tert-butyl peroxide (TBPA) was used as the radical relay precursor, providing the initiated methyl radical to start the radical relay process. Preliminary mechanistic studies were conducted, and late-stage functionalizations of natural product derivatives were performed.
Method of preparing iodine alkane by using rhodium catalysis
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Paragraph 0040-0041, (2018/04/03)
The invention relates to the field of organic synthesis and discloses a synthetic method of iodine alkane. The synthetic method of the iodine alkane, disclosed by the invention, comprises the following steps: taking olefin as a starting raw material, adding a rhodium metal catalyst, a phosphine ligand, a solvent and molecular iodine into a pressurizing reaction kettle, introducing hydrogen and then synthesizing a series of the iodine alkane by using one-step reaction. The reaction temperature is 0 to 60 DEG C, the molar ratio of the rhodium metal to the olefin is (0.00001 to 1) to (0.1 to 1) and the molar ratio of the iodine to the olefin is (0.5 to 1) to (10 to 1). The synthetic method of the iodine alkane, disclosed by the invention, has obvious advantages of wide application range, short process flow and low cost of the raw materials; the synthetic method of the iodine alkane is suitable for industrialized production of a series of the iodine alkanes.
Palladium and visible-light mediated carbonylative Suzuki-Miyaura coupling of unactivated alkyl halides and aryl boronic acids
Roslin, Sara,Odell, Luke R.
supporting information, p. 6895 - 6898 (2017/07/10)
Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.
