55743-71-0

Basic information

• Product Name: N,N-bis(2-chloroethyl)-4-nitroaniline
• CAS NO: 55743-71-0
• Molecular Formula: C₁₀H₁₂Cl₂N₂O₂
• Molecular Weight: 263.1205
• Mol File: 55743-71-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 402.7°C at 760 mmHg
• Flash Point: 197.4°C
• Density: 1.348g/cm³
• Vapor Pressure: 1.07E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: N,N-bis(2-chloroethyl)-4-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-chloroethyl)-4-nitroaniline(55743-71-0)
• EPA Substance Registry System: N,N-bis(2-chloroethyl)-4-nitroaniline(55743-71-0)

Safety Data

• Hazardous Substances Data: 55743-71-0(Hazardous Substances Data)

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 100-01-6 4-nitro-aniline 
• 350-46-9 4-Fluoronitrobenzene 
• 18226-17-0 N,N-bis(2-hydroxyethyl)-4-nitroaniline 
• 23721-18-8 N,N-bis<2-<(methylsulfonyl)oxy>ethyl>-4-nitroaniline 

Downstream Products

• 2067-58-5 4-amino-N,N-bis(2-chloroethyl)aniline 
• 1367362-64-8 C₃₀H₃₄N₄O₄S₅ 
• 1367362-63-7 C₂₆H₂₆Cl₂N₄O₄S₂ 
• 1367362-61-5 C₂₂H₂₄N₄O₂S₂ 
• 1196071-88-1 TH-1104 
• 1196071-92-7 TH-1107 
• 1196071-90-5 TH-1105 
• 2067-59-6 N,N-bis(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine 
• 1456621-48-9 N¹,N¹-bis(2-chloroethyl)-N⁴-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)benzene-1,4-diamine 
• 1456621-46-7 4-(4-(bis(2-chloroethyl)amino)phenylamino)-7-methoxyquinazolin-6-ol 
• 1456621-39-8 N¹,N¹-bis(2-chloroethyl)-N⁴-(6,7-dimethoxyquinazolin-4-yl)benzene-1,4-diamine hydrochloride 
• 180839-04-7 diprop-2-enyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate 
• 180839-02-5 di-tert-butyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate 
• 82484-59-1 4-bis-(β-chloroethyl)aminophenyl isocyanate 

Relevant articles and documents

N nitrogen mustard derivatives, two N - (2 - chloroethyl) - 1, 4 - phenylenediamine - N' - sixteen-acyl and its preparation method

The invention discloses a structural formula of a nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine, and a preparation method thereof. The preparation method comprises the following steps: preparing N,N-di(2-chloroethyl)-1,4-phenylenediamine; putting the reaction raw materials comprising the N,N-di(2-chloroethyl)-1,4-phenylenediamine, dichloromethane and triethylamine into a reactor, cooling in ice-water bath, stirring, dropwise adding a mixed solution of hexadecanoyl chloride and dichloromethane into the reactor, removing the ice-water bath after addition, conducting reaction at room temperature for 12 to 14 hours, sequentially performing washing, drying and normal-pressure distillation on the reaction liquid after the reaction is conducted completely, and purifying the distilled filter cake to obtain the product. The arylamine nitrogen mustard derivative provided by the invention can effectively reduce the toxic and side effects of nitrogen mustard on the premise of enhancing the treatment index of the nitrogen mustard, and has sterilization and inflammation-diminishing curative effects to reduce the risk of complication caused by the fact that the immunity is reduced after a patient is subjected to chemical therapy.

A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells

Herein, a novel soluble mitochondria-targeted theranostic compound, HMX-1, was presented, which was selectively activated under hypoxia with excellent mitochondria-targeting ability at the cellular level, accompanied by a dramatic increase in the fluorescence intensity. Moreover, its anti-cancer efficiency was certified both in vitro and in vivo.

Pyrazolo [1, 5 - a] pyrimidine nitrogen mustard derivative and its preparation method and tumor therapeutic use

The invention relates to pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives or medical salts thereof, as well as application of the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives or the medical salts thereof. The pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives and the medical salts thereof have the structure shown as the formula I. Pharmacological experiments show that the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives and the medical salts thereof have inhibiting effects on the proliferation of various tumor cells. Moreover, the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives are small in toxicity, have the advantages of selectivity on tumor cells, and are dual-functional anti-tumor drugs. Meanwhile, the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives are easy to synthesize, and the overall yields are high. All the advantages show that the pyrazolo[1,5-alpha] pyrimidine nitrogen mustard derivatives have great potential of being anti-tumor drugs.