55827-51-5

Basic information

• Product Name: 1-(1,3-benzodioxol-5-yl)piperazine
• Synonyms: 1-(1,3-benzodioxol-5-yl)piperazine;1-(benzo[d][1,3]dioxol-5-yl)piperazine
• CAS NO: 55827-51-5
• Molecular Formula: C₁₁H₁₄N₂O₂
• Molecular Weight: 206.24106
• EINECS: 259-842-4
• Mol File: 55827-51-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 387°Cat760mmHg
• Flash Point: 187.9°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 3.4E-06mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 1-(1,3-benzodioxol-5-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-benzodioxol-5-yl)piperazine(55827-51-5)
• EPA Substance Registry System: 1-(1,3-benzodioxol-5-yl)piperazine(55827-51-5)

Safety Data

• Hazardous Substances Data: 55827-51-5(Hazardous Substances Data)

Usage

General Description

1-(1,3-benzodioxol-5-yl)piperazine is a chemical compound that consists of a piperazine ring with a benzodioxole group attached at the 1-position. It is commonly used in scientific research as a tool to study the effects of serotonergic activity in the brain, as it acts as a selective serotonin 5-HT1A receptor agonist. 1-(1,3-benzodioxol-5-yl)piperazine has also been identified as a potential drug candidate for treating anxiety, depression, and other mood disorders due to its ability to modulate serotonin levels in the brain. Additionally, it has been investigated for its potential use in drug design and discovery for various therapeutic applications. However, it is important to note that this compound may have potential side effects and should be handled with caution.

InChI:InChI=1/C11H14N2O2/c1-2-10-11(15-8-14-10)7-9(1)13-5-3-12-4-6-13/h1-2,7,12H,3-6,8H2

Upstream product

• 110-85-0 piperazine 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 474710-26-4 4-benzo[1,3]dioxol-5-ylpiperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1059604-06-6 2-[4-(4-benzo[1,3]dioxol-5-yl-piperazin-1-ylmethyl)-5-bromo-3-(4-chloro-benzoyl)-thiophen-2-yl]-isoindole-1,3-dione 
• 549505-30-8 4-(3,4-Methylenedioxy-phenyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 

Relevant articles and documents

Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines

Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted carbonyl derivatives. Herein, we demonstrate that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to yield highly valuable trans-cyclopropylamines in good yields and high diastereoselectivities. GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this strategy.

NITROGENOUS FUSED?RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF

The present invention provides a compound having an excellent inhibitory action on activation of STAT6 and a pharmaceutical composition thereof. Inparticular, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, X represents a nitrogen-containing condensed aromatic heterocyclic group such as imidazo[1,2-a]pyridine, benzimidazole, quinazoline, quinoline, or 2,1-benzisoxazole and has (R4)n as substituent groups; Y represents a C3-8 cycloalkyl group, C4-8 cycloalkenyl group, 5- to 14-membered non-aromatic heterocyclic group, C6-14 aromatic hydrocarbon cyclic group or 5- to 14-membered aromatic heterocyclic group; n in (R4)n is 0, 1, 2 or 3, and Z groups independently represent (1) hydrogen atom, (2) amino group, (3) halogen atom, (4) hydroxyl group, (5) nitro group, (6) cyano group, (7) azido group, (8) formyl group, (9) hydroxyamino group, (10) sulfamoyl group, (11) guanodino group, (12) oxo group, (13) C2-6 alkenyl group, (14) C1-6 alkoxy group, (15) C1-6 alkylhydroxyamino group, (16) halogenated C1-6 alkyl group, (17) halogenated C2-6 alkenyl group, (18) (i) C3-7cycloalkyl group, (ii) C3-7cycloalkenyl group, (iii) 5- to 14-membered non-aromatic heterocyclic group, each of which may have one or more substituent groups Q, or (19) formula -M1-M2-M3, R1 represents (1) hydrogen atom, (2) halogen atom, (3) hydroxyl group, (4) nitro group, (5) cyano group, (6) halogenated C1-6 alkyl group, (7) C2-6 alkyl group substituted with a hydroxyl or cyano group, (8) C2-6 alkenyl group, or (9) formula -L1-L2-L3, and R2 represents a hydrogen atom or a protecting group; and R3 represents a hydrogen atom, halogen atom, cyano group, amino group, C1-4 alkyl group or halogenated C1-4 alkyl group.

Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst

A Pd/P(t-Bu), catalyst system has revealed very high activity and selectivity for the amination of N-(hetero)aryl halides with unprotected piperazine. A wide variety of N-(hetero)arylpiperazines could be prepared using this catalyst. Turnover numbers up to 6400mol/mol have been obtained.