55848-87-8

Basic information

• Product Name: t-butyl 5-hydroxy-3-oxo-5-phenylpentanoate
• Synonyms: t-butyl 5-hydroxy-3-oxo-5-phenylpentanoate
• CAS NO: 55848-87-8
• Molecular Weight: 264.321
• Mol File: 55848-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: t-butyl 5-hydroxy-3-oxo-5-phenylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 5-hydroxy-3-oxo-5-phenylpentanoate(55848-87-8)
• EPA Substance Registry System: t-butyl 5-hydroxy-3-oxo-5-phenylpentanoate(55848-87-8)

Safety Data

• Hazardous Substances Data: 55848-87-8(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 100-52-7 benzaldehyde 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 849905-14-2 (R)-5-hydroxy-3-oxo-5-phenyl-pentanoic acid tert-butyl ester 
• 18458-72-5 trans-2,6-diphenyltetrahydro-4H-pyran-4-one 
• 18458-71-4 cis-2,6-diphenyltetrahydro-4H-pyran-4-one 

Relevant articles and documents

The one-pot, multi-component construction of highly substituted tetrahydropyran-4-ones using the Maitland-Japp reaction

A one-pot, multi-component reaction for the synthesis of highly substituted tetrahydropyran-4-ones, based on the long forgotten Maitland-Japp reaction has been realised. Two different aldehydes and a derivative of a β-ketoester can be condensed regioselectively in the presence of a Lewis acid to form tetrahydropyran-4-ones in excellent yields. The diastereoselectively of the reaction was found to be dependant upon the nature of the Lewis acid and the temperature at which the reaction was carried out. This procedure was also extended to the formation of tetrahydropyran-4-ones in greater than 95% enantiomeric excess. The Royal Society of Chemistry 2005.