55912-03-3

Basic information

• Product Name: 4-hydroxyderricin
• Synonyms: 4-hydroxyderricin;(E)-1-[2-Hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;2',4-Dihydroxy-3'-(3-methyl-2-butenyl)-4'-methoxy-trans-chalcone
• CAS NO: 55912-03-3
• Molecular Formula: C₂₁H₂₂O₄
• Molecular Weight: 338.4
• Mol File: 55912-03-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 136.0-137.0 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 542°Cat760mmHg
• Flash Point: 190.8°C
• Appearance: /
• Density: 1.181g/cm³
• Vapor Pressure: 2.32E-12mmHg at 25°C
• Refractive Index: 1.622
• PKA: 7.83±0.40(Predicted)
• CAS DataBase Reference: 4-hydroxyderricin(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxyderricin(55912-03-3)
• EPA Substance Registry System: 4-hydroxyderricin(55912-03-3)

Safety Data

• Hazardous Substances Data: 55912-03-3(Hazardous Substances Data)

Usage

General Description

4-hydroxyderricin is a chemical compound that is found in plants from the Echinacea family, particularly in the roots of Echinacea angustifolia. It is a flavonoid with antioxidant and anti-inflammatory properties, and has been shown to have potential therapeutic effects. Research suggests that 4-hydroxyderricin may have anti-cancer, anti-microbial, and anti-viral properties, making it a promising candidate for the development of new pharmaceuticals and natural health products. Additionally, studies have also indicated that 4-hydroxyderricin may have neuroprotective and anti-obesity effects, highlighting its potential applications in the medical and nutritional fields. Overall, the discovery and study of 4-hydroxyderricin has opened up exciting possibilities for its use in medicine and healthcare.

InChI:InChI=1/C21H22O4/c1-14(2)4-10-18-20(25-3)13-11-17(21(18)24)19(23)12-7-15-5-8-16(22)9-6-15/h4-9,11-13,22,24H,10H2,1-3H3/b12-7+

Upstream product

• 1092462-94-6 2'-hydroxyl-4'-methoxy-4-methoxymethoxy-3'-prenyl-chalcone 
• 52601-06-6 1-(2-hydroxy-4-methoxy-3-(3-methyl-butyl-2-ene-1-yl)phenyl)ethanone 
• 19825-40-2 2,4-Dihydroxy-3-C-prenylacetophenone 
• 54730-26-6 4-methoxymethoxy-3-(3,3-dimethylallyl)-2-hydroxyacetophenone 
• 1314539-20-2 2'-prenyloxy-4'-methoxymethoxyacetophenone 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 1393921-61-3 1-(4-methoxy-2-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethanone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 1092462-95-7 4'-methoxy-4-methoxymethoxy-2'-prenyloxychalcone 
• 123-08-0 4-hydroxy-benzaldehyde 
• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 

Downstream Products

• 132998-83-5 (E)-1-(2-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-4-methoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one 
• 132998-84-6 xanthoangelol E 
• 791112-99-7 4-tetrahydropyranyloxy-2'-hydroxy-3'-prenyl-4'-methoxychalcone 
• 791113-18-3 4-acetoxy-2'-hydroxy-3'-prenyl-4'-methoxychalcone 
• 62536-71-4 4'-methoxy-4.2'-diacetoxy-trans-chalcone 

Relevant articles and documents

Preparation method and application of natural product Xanthoangelol D and derivative thereof

The invention discloses a preparation method and application of an isopentenyl chalcone natural product and a derivative thereof. The structural general formula (I) and (II) of the isopentenyl chalcone natural product and the derivative thereof are as follows. Compared with a novel isopentenyl chalcone derivative, the obtained natural product Xanthoangelol D has inhibitory activity improved to a certain degree on bacillus subtilis. The preparation rout of the preparation method has fewer process steps, raw materials are easily available, and the preparation method is suitable for industrial production.

Synthesis of biologically active natural component 4-hydroxyderricin through water-accelerated [3,3]-sigmatropic rearrangement

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Synthesis of 4-hydroxyderricin and related derivatives

Naturally occurring chalcones, namely 4-hydroxyderricin (1), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4), were first synthesized and evaluated for antibacterial activities.