55934-01-5

Basic information

• Product Name: 2,4,5-Trichloropyridine
• Synonyms: 2,4,5-TRIFLUOROANILINE;2,4,5-TRICHLOROPYRIDINE;Pyridine, 2,4,5-trichloro-;2,4,5-Trichloropyridine 98%;2,4,5-Trifluoroaniline ISO 9001：2015 REACH
• CAS NO: 55934-01-5
• Molecular Formula: C₅H₂Cl₃N
• Molecular Weight: 182.43508
• Mol File: 55934-01-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 8-9 °C
• Boiling Point: 219.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.539±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.24±0.10(Predicted)
• CAS DataBase Reference: 2,4,5-Trichloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-Trichloropyridine(55934-01-5)
• EPA Substance Registry System: 2,4,5-Trichloropyridine(55934-01-5)

Safety Data

• RIDADR: UN2810
• Hazardous Substances Data: 55934-01-5(Hazardous Substances Data)

Usage

General Description

2,4,5-Trichloropyridine is a highly toxic and aromatic organic compound with the chemical formula C5H2Cl3N. It is used as an intermediate in the production of pesticides, particularly herbicides. This chemical is a white to light beige solid with a strong, pungent odor. It is often listed as a hazardous substance due to its potential for causing irritation to the skin, eyes, and respiratory system, as well as being harmful if ingested or inhaled. Additionally, 2,4,5-Trichloropyridine is considered to be extremely toxic to aquatic life and can have long-lasting effects on the environment. Therefore, proper handling and disposal of this chemical is essential to prevent negative impacts on human health and the environment.

InChI:InChI=1S/C5H2Cl3N/c6-3-1-5(8)9-2-4(3)7/h1-2H

Upstream product

• 856965-66-7 4,5-dichloro-2-hydroxypyridine 
• 7321-93-9 4,6-dichloropyridin-3-ylamine 
• 103766-25-2 5-Chloro-2,4-dihydroxypyridine 
• 14401-91-3 picoline hydrochloride 
• 57905-79-0 2,4,5-trihydroxypyridine 
• 188577-68-6 4,5-dichloro-2-aminopyridine 
• 857991-71-0 2-ethoxy-4,5-dichloro-pyridine 
• 856851-45-1 4-chloro-2-ethoxypyridine 
• 6975-44-6 4,6-dihydroxynicotinic acid ethyl ester 
• 40296-46-6 ethyl 4,6-dichloronicotinate 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 166526-03-0 4,6-dichloropyridine-3-carbonitrile 
• 856850-46-9 2,4-diethoxy-5-chloro-pyridine 

Downstream Products

• 405230-82-2 2,5-dichloro-4-amino-pyridine 
• 856965-66-7 4,5-dichloro-2-hydroxypyridine 
• 1201935-41-2 2-[(2,5-dichloro-4-pyridinyl)amino]-N-(methyloxy)benzamide 

Relevant articles and documents

Preparation method of 4,5-dichloro-2-hydroxypyridine

The invention discloses a preparation method of 4,5-dichloro-2-hydroxypyridine. The method comprises the following steps that S1, chlorine-containing organic matter and 2,4,5-trihydroxy pyridine are added into a reaction bottle in sequence, heating reflux is conducted for 16-48 hours, concentration and extraction are conducted, organic phases are combined, a drying agent is added to the organic phases, filtering and rotary evaporation are conducted, and a solvent is removed for obtaining a 2,4,5-trichloropyridine crude product; S2, the 2,4,5-trichloropyridine crude product is dissolved in a polar solvent, an aqueous NaOH solution is added at 0-25 DEG C, a reaction is conducted for 1-6 hours at 0-25 DEG C, extraction is conducted, organic phases are combined, a drying agent is added to theorganic phases, filtering and rotary evaporation are conducted, and a solvent is removed for obtaining a 4,5-dichloro-2-hydroxypyridine crude product; S3, the 4,5-dichloro-2-hydroxypyridine crude product is subjected to recrystallization for obtaining a 2,4,5-trichloropyridine pure product. According to the preparation method of the 4,5-dichloro-2-hydroxypyridine, the raw materials are easy to obtain, the preparation process and purification steps are simple, and industrialization is conveniently achieved.

STRONG CHLORINATION OF 2-PICOLINE

The strong thermal and photochemical chlorination of 2-picoline hydrochloride at 80-150 deg.C was investigated.It occurs with change in the phase state of the reaction mixture.Among the chlorination products there were 17 compounds, 15 of which were isolated and identified.The main factor affecting the degree of chlorination is temperature, with increase in which the limiting degree of chlorination in the investigated range decreases.The penta-, hexa-, and heptachloro derivatives are formed mainly by initial chlorination of the pyridine ring with subsequent chlorination of the methyl group.