55989-13-4

Basic information

• Product Name: 3-(4-chlorophenyl)piperidine
• Synonyms: 3-(4-chlorophenyl)piperidine;3-(4-chlorophenyl)piperidine(SALTDATA: FREE)
• CAS NO: 55989-13-4
• Molecular Formula: C₁₁H₁₄ClN
• Molecular Weight: 195.68856
• Mol File: 55989-13-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 293.9°C at 760 mmHg
• Flash Point: 131.6°C
• Appearance: /
• Density: 1.095g/cm³
• Vapor Pressure: 0.00167mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 3-(4-chlorophenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)piperidine(55989-13-4)
• EPA Substance Registry System: 3-(4-chlorophenyl)piperidine(55989-13-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 55989-13-4(Hazardous Substances Data)

Usage

General Description

3-(4-chlorophenyl)piperidine, also known as N-4-chlorophenylpiperidine, is a chemical compound that belongs to the class of piperidine derivatives. It is a heterocyclic organic compound with a piperidine backbone and a 4-chlorophenyl group attached to the nitrogen atom. 3-(4-chlorophenyl)piperidine has applications in medicinal chemistry, particularly in the synthesis of pharmaceuticals and research chemicals. It may also have potential uses as a reagent in organic synthesis and in the development of new chemical compounds. However, it is important to handle this compound with care, as it may have potential health hazards and should be used in accordance with proper safety guidelines and procedures.

InChI:InChI=1/C11H14ClN/c12-11-5-3-9(4-6-11)10-2-1-7-13-8-10/h3-6,10,13H,1-2,7-8H2

Upstream product

• 106-39-8 bromochlorobenzene 
• 1018699-96-1 tert-butyl 3-(4-chlorophenyl)piperidine-1-carboxylate 
• 885693-20-9 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 1187318-69-9 diphenylmethanone [4-(1-benzylpiperidin-3-yl)phenyl]hydrazone 
• 1602924-08-2 3-(3-(4-chlorophenyl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol 
• 1602923-16-9 (4-chlorophenyl)-carbamic acid 1-[3-(4-chlorophenyl)-piperidin-1-ylmethyl]-2,2,2-trifluoro ethyl ester 
• 1187318-68-8 1-benzyl-3-(4-chlorophenyl)piperidine 
• 1106937-63-6 3-(4-chlorophenyl)-1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidine 
• 945978-25-6 2-chloro-4-[3-(4-chlorophenyl)-piperidin-1-yl]-[1, 3, 5]triazine 

Relevant articles and documents

Synthesis method of (S)-3-(4-chlorophenyl)-piperidine

The invention relates to a synthetic method of (S)-3-(4-chlorophenyl)-piperidine. The invention mainly aims to solve the technical problems of harsh reaction conditions, expensive catalysts, high cost, unsuitability for large-scale production and the like when optically pure (S)-3-(4-chlorophenyl)-piperidine is prepared by hydrogenating a pyridine ring and then utilizing chiral SFC. The synthesis method comprises the following four steps: (1) alpha-site alkylation of 4-chlorobenzyl cyanide; (2) reduction of 5-chloro-2-(4-chlorophenyl)valeronitrile; (3) cyclization of the 5-chloro-2-(4-chlorphenyl)amyl-1-amine to obtain (RS)-3-(4-chlorophenyl)-piperidine; and (4) chemical resolution of the (RS)-3-(4-chlorophenyl)-piperidine to obtain a final product. A target product with an optical purity reaching 98% or above is obtained through four-step reaction. The method is high in yield, low in cost, simple and convenient to operate and purify, good in economic benefits and more suitable for industrial production.