56187-37-2

Basic information

• Product Name: 3,5-Dichloro-4-pyridone-N-acetic acid
• Synonyms: 3,5-DICHLORO-4-OXO-1(4H)-PYRIDINEACETIC ACID;3,5-dichloro-4-oxo-1-pyridineacetic acid;3,5-DICHLORO-4-PYRIDONE-1-ACETIC ACID;3,5-DICHLORO-4-PYRIDONE-N-ACETIC ACID;3,5-DICHLORO PYRIDONE ACETIC ACID;3,5-DICHLOROPYRID-4-ONE-1-ACETIC ACID;TIMTEC-BB SBB003343;3,5-dichloro-4-oxo-4H-pyridine-1-acetic acid
• CAS NO: 56187-37-2
• Molecular Formula: C₇H₅Cl₂NO₃
• Molecular Weight: 222.03
• EINECS: 260-040-1
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine Series
• Mol File: 56187-37-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 259-263 °C
• Boiling Point: 364.1 °C at 760 mmHg
• Flash Point: 174 °C
• Appearance: white powder
• Density: 1.65 g/cm³
• Vapor Pressure: 2.71E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 3.60±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3,5-Dichloro-4-pyridone-N-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-4-pyridone-N-acetic acid(56187-37-2)
• EPA Substance Registry System: 3,5-Dichloro-4-pyridone-N-acetic acid(56187-37-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-37
• Hazardous Substances Data: 56187-37-2(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

3,5-Dichloro-4-pyridone-1-acetic acid is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C7H5Cl2NO3/c8-4-1-10(3-6(11)12)2-5(9)7(4)13/h1-2H,3H2,(H,11,12)/p-1

Upstream product

• 218772-96-4 4-piperidon-1-acetic acid 
• 41979-39-9 4-piperidone hydrochloride 
• 79-11-8 chloroacetic acid 
• 17228-70-5 3,5-dichloropyridin-4-one 

Downstream Products

• 56187-47-4 cefazedone 
• 70150-41-3 2-(3,5-dichloro-4-oxo-4H-pyridin-1-yl)-N-((5aR)-1,7-dioxo-(5ar)-1,4,6,7-tetrahydro-3H,5aH-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6t-yl)-acetamide 

Relevant articles and documents

Preparation method of 3,5-dihalogenated-4-pyridone-1-acetic acid

The invention provides a preparation method of 3, 5-dihalogenated-4-pyridone-1-acetic acid, and particularly relates to a preparation method of 3,5-dichloro-4-pyridone-1-acetic acid. The method comprises the following steps: performing a substitution reaction on piperidine-4-ketone hydrochloride (II) with chloroacetic acid in the presence of a proper solvent and an acid-binding agent to obtain 4-piperidone-1-acetic acid (III), carrying out a halogenation reaction on the 4-piperidone-1-acetic acid (III) and a halogenation reagent to obtain 3,3,5,5-tetrahalogenated-4-piperidone-1-acetic acid (IV), carrying out an elimination reaction in the presence of an alkali to remove hydrogen halide, and performing acidification with hydrochloric acid to obtain the 3,5-dihalo-4-pyridinone-1-acetic acid.The method has the advantages of cheap and easily available raw materials, low cost, simple operation, easy realization, less wastewater generation amount, environmental protection, high reaction selectivity, high product yield and purity, and suitableness for industrial production.