5623-81-4

Basic information

• Product Name: Cyclopentyl Acetaldehyde
• Synonyms: Cyclopentyl Acetaldehyde;2-CYCLOPENTYLACETALDEHYDE;Cyclopentaneacetaldehyde
• CAS NO: 5623-81-4
• Molecular Formula: C₇H₁₂O
• Molecular Weight: 112.16958
• Product Categories: Pharmaceutical Intermediates
• Mol File: 5623-81-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 165.3 °C at 760 mmHg
• Flash Point: 44.9 °C
• Appearance: /
• Density: 0.907 g/cm³
• CAS DataBase Reference: Cyclopentyl Acetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentyl Acetaldehyde(5623-81-4)
• EPA Substance Registry System: Cyclopentyl Acetaldehyde(5623-81-4)

Safety Data

• Hazardous Substances Data: 5623-81-4(Hazardous Substances Data)

Usage

Uses

Cyclopentaneacetaldehyde is a reagent used in the preparation of thiomethanes as nonpeptidic potent HIV-1 protease inhibitors. As well as pyrimidinones as HIV-1 replication inhibitors.

Synthesis Reference(s)

Canadian Journal of Chemistry, 48, p. 868, 1970 DOI: 10.1139/v70-142

Upstream product

• 23985-40-2 tricyclopentylborane 
• 59648-89-4 1,2-dimethoxyethenyllithium 
• 1528-30-9 methylenecyclopentane 
• 201230-82-2 carbon monoxide 
• 497-36-9 (1S,4R)-bicyclo[2.2.1]heptan-2-ol 
• 18322-54-8 ethyl cyclopentylacetate 
• 1903-22-6 ethyl cyclopentylideneacetate 
• 120-92-3 cyclopentanone 
• 1123-00-8 2-cyclopentylacetic acid 
• 766-00-7 2-cyclopentyl-ethanol 
• 26939-18-4 2,4,4,6-tetramethyl-5,6-dihydro-4H-1,3-oxazine 
• 1556-18-9 cyclopentyl iodide 

Downstream Products

• 742-20-1 cyclopenthiazide 
• 95946-25-1 2-benzyl-6-chloro-3-cyclopentylmethyl-1,1-dioxo-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 
• 151386-28-6 2-(2-cyclopentylethyl)amino-2'-fluorodiphenylamine 
• 612504-42-4 2-amino-5-cyclopentyl-thiophene-3-carbonitrile 
• 151620-69-8 3-amino-1-N-(2-cyclopentylethyl)-2,4-dioxo-5-N-(2-fluorophenyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 153930-53-1 1-(2-cyclopentylethyl)-2,4-dioxo-5-(2-fluorophenyl)-3-isocyanato-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 151386-29-7 1-N-(2-cyclopentylethyl)-2,4-dioxo-5-N-(2-fluorophenyl)-3-phenylhydrazono-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 158743-79-4 diphenylmethyl 7β-<(Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)-4-cyclopentyl-2-butenoylamino>-3-cephem-4-carboxylate 
• 68104-99-4 ethyl 4-cyclopentyl-3-oxobutanoate 
• 67590-51-6 4-Cyclopentyl-2,6,7-trioxa-1-phospha-bicyclo[2.2.2]octane 1-oxide 
• 683746-68-1 trans-N-(1-acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)piperidin-4-yl]acrylamide 
• 84803-66-7 sodium 2-cyclopentyl-1-hydroxyethanesulfonate 
• 5662-91-9 4-cyclopentylbut-2-enal 
• 1312017-82-5 1-benzenesulfonyl-2-(2-cyclopentyl-1-hydroxy-ethyl)-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester 

Relevant articles and documents

Hydroformylation of 1,6-Dienes with Carbonylhydridotris(triphenylphosphine)rhodium

Hydroformylation of a number of 1,6-dienes has been achieved at room temperature and atmospheric pressure using as catalyst.Octa-1,6-dienes are hydroformylated specifically at the terminal double bond and good selectivity for the n-aldehyde is observed when a 2:1 mixture of hydrogen and carbon monoxide are used.Both mono- and di-formyl derivatives are formed from 4,4-diacetylhepta-1,6-diene, with a strong preference for n-aldehydes.The effect of catalyst concentration on product distribution is reported.Octa-1,3,7-triene can be selectively hydroformylated by protecting the diene moiety as its cycloadduct with sulphur monoxide or dioxide, and whilst methylenecyclopentane undergoes regiospecific hydroformylation, methylenecyclobutane is isomerised to methylcyclobutene.

Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols

An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

Structure-guided directed evolution of choline oxidase has been carried out by using the oxidation of hexan-1-ol to hexanal as the target reaction. A six-amino-acid variant was identified with a 20-fold increased kcat compared to that of the wild-type enzyme. This variant enabled the oxidation of 10 mm hexanol to hexanal in less than 24 h with 100 % conversion. Furthermore, this variant showed a marked increase in thermostability with a corresponding increase in Tm of 20 °C. Improved solvent tolerance was demonstrated with organic solvents including ethyl acetate, heptane and cyclohexane, thereby enabling improved conversions to the aldehyde by up to 30 % above conversion for the solvent-free system. Despite the evolution of choline oxidase towards hexan-1-ol, this new variant also showed increased specific activities (by up to 100-fold) for around 50 primary aliphatic, unsaturated, branched, cyclic, benzylic and halogenated alcohols.

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.