56230-65-0

Basic information

• Product Name: 1-(4-methylpiperazin-1-yl)-2-phenylethanone
• Synonyms: 1-(4-methylpiperazin-1-yl)-2-phenylethanone
• CAS NO: 56230-65-0
• Molecular Weight: 218.299
• Mol File: 56230-65-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(4-methylpiperazin-1-yl)-2-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylpiperazin-1-yl)-2-phenylethanone(56230-65-0)
• EPA Substance Registry System: 1-(4-methylpiperazin-1-yl)-2-phenylethanone(56230-65-0)

Safety Data

• Hazardous Substances Data: 56230-65-0(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 103-82-2 phenylacetic acid 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 135181-94-1 2-(4-methylpiperazin-1-yl)-3,4-diphenylquinoline 
• 31576-87-1 6-chloro-2-(4-methylpiperazin-1-yl)-3,4-diphenylquinoline 
• 102165-56-0 1-[(1-hydroxy-cyclohexyl)-phenyl-acetyl]-4-methyl-piperazine 

Relevant articles and documents

Water-Tolerant and Atom Economical Amide Bond Formation by Metal-Substituted Polyoxometalate Catalysts

A simple, safe, and inexpensive amide bond formation directly from nonactivated carboxylic acids and free amines is presented in this work. Readily available Zr(IV)- and Hf(IV)-substituted polyoxometalates (POM) are shown to be catalysts for the amide bond formation reaction under mild conditions, low catalyst loading, and without the use of water scavengers, dry solvents, additives for facilitating the amine attack, or specialized experimental setups commonly employed to remove water. Detailed mechanistic investigations revealed the key role of POM scaffolds which act as inorganic ligands to protect Zr(IV) and Hf(IV) Lewis acidic metals against hydrolysis and preserve their catalytic activity in amide bond formation reactions. The catalysts are compatible with a range of functional groups and heterocycles useful for medicinal, agrochemical, and material chemists. The robustness of the Lewis acid-POM complexes is further supported by the catalyst reuse without loss of activity. This prolific combination of Zr(IV)/Hf(IV) and POMs inaugurates a powerful class of catalysts for the amide bond formation, which overcomes key limitations of previously established Zr(IV)/Hf(IV) salts and boron-based catalysts.

Direct synthesis of amides from carboxylic acids and amines using B(OCH2CF3)3

B(OCH2CF3)3, prepared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad range of amines. In most cases, the amide products can be purified by a simple filtration procedure using commercially available resins, with no need for aqueous workup or chromatography. The amidation of N-protected amino acids with both primary and secondary amines proceeds effectively, with very low levels of racemization. B(OCH2CF3)3 can also be used for the formylation of a range of amines in good to excellent yield, via transamidation of dimethylformamide.