5625-62-7Relevant articles and documents
Novel substituted heteroaromatic piperazine and piperidine derivatives as inhibitors of human enterovirus 71 and coxsackievirus A16
Zhang, Xian,Wang, Hongliang,Li, Yuhuan,Cao, Ruiyuan,Zhong, Wu,Zheng, Zhibing,Wang, Gang,Xiao, Junhai,Li, Song
, p. 5059 - 5071 (2013/07/19)
A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackievirus A16 with low cytotoxicity.
Application of piperazine-derived hydrazone linkers for alkylation of solid-phase immobilized ketones
Lazny, Ryszard,Michalak, Michal
, p. 1931 - 1934 (2007/10/03)
The preparation and application of three new solid supports with piperazine-derived hydrazine anchoring groups are described. The supports were used for immobilization of ketones. The ketones: cyclohexanone, 4-tert-butylcyclohexanone, 3-pentanone and tropinone, which were bound to polymers in the form of their hydrazones, were deprotonated with LDA and alkylated with propyl iodide or benzyl bromide. The resulting alkylated products were cleaved off the solid support on treatment with trifluoroacetic acid in dichloromethane. Linkers with 6- and 3-carbon atom spacers gave better results than the simple N-aminopiperazine linker.