5635-67-6

Basic information

• Product Name: (3,4-Dichlorobenzyl)methylamine
• Synonyms: 1-(3,4-Dichlorophenyl)-N-MethylMethanaMine;1-(3,4-Dichlorophenyl);N-(3,4-DICHLOROBENZYL)-N-METHYLAMINE;3,4-DICHLORO-N-METHYLBENZYLAMINE;(3,4-DICHLOROBENZYL)METHYLAMINE;(3,4-DICHLOROBENZYL)METHYLAMINE 95%;(3,4-dichlorophenyl)-N-methylmethanamine;N-(3,4-Dichlorobenzyl)-N-methylamine ,97%
• CAS NO: 5635-67-6
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• Mol File: 5635-67-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 242.832 °C at 760 mmHg
• Flash Point: 100.661 °C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 0.0332mmHg at 25°C
• PKA: 8.77±0.10(Predicted)
• CAS DataBase Reference: (3,4-Dichlorobenzyl)methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-Dichlorobenzyl)methylamine(5635-67-6)
• EPA Substance Registry System: (3,4-Dichlorobenzyl)methylamine(5635-67-6)

Safety Data

• Hazardous Substances Data: 5635-67-6(Hazardous Substances Data)

Usage

General Description

(3,4-Dichlorobenzyl)methylamine is a chemical compound that is known for its use as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and other compounds. It is a derivative of benzylamine, with the addition of two chlorine atoms on the 3 and 4 positions of the benzene ring. (3,4-Dichlorobenzyl)methylamine is often used in the synthesis of various pharmaceuticals, such as antihistamines and local anesthetics, as well as in the production of pesticides and other agricultural chemicals. It has also been studied for its potential use in the treatment of neurological disorders and as a building block in the creation of novel drug compounds. Overall, (3,4-Dichlorobenzyl)methylamine is a versatile and important chemical with a wide range of applications in various industries.

InChI:InChI=1/C8H9Cl2N/c1-11-5-6-2-3-7(9)8(10)4-6/h2-4,11H,5H2,1H3/p+1

Upstream product

• 593-51-1 methylamine hydrochloride 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 74-89-5 methylamine 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 17947-66-9 (3,4-dichloro-benzylidene)-methyl-amine 
• 6077-76-5 3,4-dichloro-N-methylbenzamide 

Downstream Products

• 55245-69-7 C₉H₈Cl₃NO 
• 74654-94-7 2-Diethoxymethyl-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester 
• 92144-31-5 2,4-Diamino-quinazoline-6-sulfonic acid (3,4-dichloro-benzyl)-methyl-amide 
• 74655-35-9 2-Diethoxymethyl-6-methyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester 
• 74655-01-9 4-(2-Cyano-phenyl)-2-diethoxymethyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-{2-[(3,4-dichloro-benzyl)-methyl-amino]-ethyl} ester 3-ethyl ester 
• 93683-75-1 6-[(3,4-Dichloro-benzyl)-methyl-amino]-3-nitro-pyridine-2-carbonitrile 
• 1450742-93-4 N-(3,4-dichlorobenzyl)-7-(4-fluorophenyl)-5-(2-hydroxyethyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-99-0 N-(3,4-dichlorobenzyl)-5-(3-(dimethylamino)propyl)-7-(4-fluorophenyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-95-6 N-(3,4-dichlorobenzyl)-5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1450742-86-5 N-(3,4-dichlorobenzyl)-7-(4-fluorophenyl)-N,5-dimethyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide 
• 1415091-51-8 4-chloro-N-(3,4-dichlorobenzyl)-N,5-dimethyl-1-(4-(naphthalen-2-ylsulfonylcarbamoyl)-2-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)phenyl)-1H-pyrazole-3-carboxamide 
• 1259392-25-0 C₂₈H₂₆Cl₂N₂O₅S 
• 67746-85-4 N-(3,4-dichlorobenzyl)-N-methyl-1H-imidazole-1-carboxamide 

Relevant articles and documents

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

Increased CK2 levels are prevalent in many cancers. Combined with the critical role CK2 plays in many cell-signaling pathways, this makes it a prime target for down regulation to fight tumour growth. Herein, we report a fragment-based approach to inhibiting the interaction between CK2α and CK2β at the α-β interface of the holoenzyme. A fragment, CAM187, with an IC50 of 44 μM and a molecular weight of only 257 gmol?1 has been identified as the most promising compound. Importantly, the lead fragment only bound at the interface and was not observed in the ATP binding site of the protein when co-crystallised with CK2α. The fragment-like molecules discovered in this study represent unique scaffolds to CK2 inhibition and leave room for further optimisation.

Benzylamines: Synthesis and evaluation of antimycobacterial properties

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.