56414-69-8Relevant articles and documents
Design, synthesis, and application of chiral nonracemic lithium amide bases in enantioselective deprotonation of epoxides
Bhuniya, Debnath,DattaGupta, Arpita,Singh, Vinod K.
, p. 6108 - 6113 (2007/10/03)
The reaction of epoxides with chiral nonracemic lithium amide bases, designed and prepared from (R)-phenylglycine, has been studied in detail. A maximum of 80% ee was obtained for conversion of cyclohexene oxide to (S)-2-cyclohexen-1-ol. Enantioselective deprotonation of a variety of other epoxides was studied. A cyclopentanoid core unit for prostaglandin synthesis was synthesized in 97% ee.