56425-91-3Relevant articles and documents
Iron-Catalyzed Cleavage Reaction of Keto Acids with Aliphatic Aldehydes for the Synthesis of Ketones and Ketone Esters
Zhou, Fangyuan,Li, Lesong,Lin, Kao,Zhang, Feng,Deng, Guo-Jun,Gong, Hang
, p. 4246 - 4250 (2020/03/11)
The radical–radical coupling reaction is an important synthetic strategy. In this study, the iron-catalyzed radical–radical cross-coupling reaction based on the decarboxylation of keto acids and decarbonylation of aliphatic aldehydes to obtain valuable aryl ketones is reported for the first time. Remarkably, when tertiary aldehydes were used as carbonyl sources, ketone esters were selectively obtained instead of ketones. The gram-scale preparation of aryl ketone through this strategy was easily achieved by using only 3 mol % of the iron catalyst. As a proof-of-concept, the bioactive molecule flurprimidol was synthesized in two steps by using this strategy.
O-Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O-Carboxydifluoromethylation and Decarboxylative Fluorination
Zhou, Min,Ni, Chuanfa,He, Zhengbiao,Hu, Jinbo
supporting information, p. 3754 - 3757 (2016/08/16)
A new strategy for the synthesis of aryl trifluoromethyl ethers (ArOCF3) by combining O-carboxydifluoromethylation of phenols and subsequent decarboxylative fluorination is reported. This protocol allows easy construction of functionalized trifluoromethoxybenzenes and trifluoromethylthiolated arenes (ArSCF3) in moderate to good yields. Moreover, it utilizes accessible and inexpensive reagents sodium bromodifluoroacetate and SelectFluor II and, thus, is practical for O-trifluoromethylation of phenols. The potential application of this method is demonstrated with the preparation of a plant-growth regulator, Flurprimidol.
Plant growth regulating formulations
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, (2008/06/13)
Plant growth regulating preparations comprising: (a) 0.1-20 wt. % of a 16,17-dihydro gibberellin of formula (Ia) or (Ib); (b) up to 99.9 wt. % of a formulation additive selected from: (b1) the reaction products of triglycerides based on carboxylic acids having 2-30C and ethylene oxide and/or propylene oxide in the presence of a base, and/or (b2) fatty acid alcohol polyethoxylates; (c) up to 50 wt. % of an organic solvent; (d) 0.1-50 wt. % of a formulation auxiliary different from (b1) and (b2); (e) up to 50 wt. % of additional plant growth regulating compounds can be used in agriculture and horticulture to induce the desired effects on, for example, seed germination and seedling growth, rooting, dormancy, juvenility, maturity and senescence, flowering, abscission of leaves, flowers and fruit, fruit set and development, tuber formation, growth of shoot and root, photoassimilation, control of unwanted plants and senescence of whole plants or single organs. The 16,17-dihydroGA's are used to synergize the biological activity of exogenously supplied gibberellins. Particularly in graminaceous species, the compounds synergize the action of exogenous GA's and can, thus, be used to increase the yield of malt and decrease the amount of time required for the malting process, increase the yield of sugar cane and stimulate germination and seedling development in rice, wheat, barley, oats, rye, maize, sorghum, turf grasses and other plant species.
