56428-57-0

Basic information

• Product Name: uridine 5'-(phosphoimidazolate)
• Synonyms: uridine 5'-(phosphoimidazolate)
• CAS NO: 56428-57-0
• Molecular Formula: C₁₂H₁₅N₄O₈P
• Molecular Weight: 374.2433
• Mol File: 56428-57-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.98g/cm³
• CAS DataBase Reference: uridine 5'-(phosphoimidazolate)(CAS DataBase Reference)
• NIST Chemistry Reference: uridine 5'-(phosphoimidazolate)(56428-57-0)
• EPA Substance Registry System: uridine 5'-(phosphoimidazolate)(56428-57-0)

Safety Data

• Hazardous Substances Data: 56428-57-0(Hazardous Substances Data)

Upstream product

• 58-97-9 5'-Uridylic Acid 
• 104619-51-4 di(1H-imidazol-1-yl)methanimine 
• 3387-36-8 disodium uridine-5'-monophosphate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 288-32-4 1H-imidazole 
• 647032-50-6 UMP triethylammonium salt 
• 3106-18-1 uridine-5'-monophosphate sodium 
• 62540-53-8 Trioctyl-amine; compound with phosphoric acid mono-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester 

Downstream Products

• 58-97-9 5'-Uridylic Acid 
• 3803-29-0 [5']uridylic acid monofluoride 
• 2616-64-0 UDP-glucuronic acid 
• 133-89-1 UDP-glucose 
• 58-98-0 UDP 
• 3616-06-6 UDP-xylose 
• 19817-92-6 uridine 5'-triphosphate sodium salt 

Relevant articles and documents

Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5′-polyphosphates

A series of dinucleoside 5-polyphosphates UpnU (n = 2-7) was synthesized. Their relative potencies as agonists at the G-protein-coupled receptors P2Y1, P2Y2, P2Y4, and P2Y6 were determined by intracellular calcium measurements using fluorescent imaging techniques. The correlation of phosphate chain length to activities at these receptors is discussed.

SULFAMIDE LINKER, CONJUGATES THEREOF, AND METHODS OF PREPARATION

The present invention relates to a compound comprising an alpha-end and an omega-end, the compound comprising on the alpha-end a reactive group Qlcapable of reacting with a functional group F1present on a biomolecule and on the omega-end a target molecule, the compound further comprising a group according to formula (1) or a salt thereof: Said compound may also be referred to as a linker-conjugate. The invention also relates to a process for the preparation of a bioconjugate, the process comprising the step of reacting a reactive group Q1of a linker-conjugate according to the invention with a functional group F1of a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention. In a preferred embodiment, the invention concerns a process for the preparation of a bioconjugate via a cycloaddition, such as a (4+2)-cycloaddition (e.g. a Diels-Alder reaction) or a (3+2)-cycloaddition (e.g. a 1,3-dipolar cycloaddition).

Synthesis of nucleoside phosphosulfates

We describe an efficient and scalable procedure for the chemical synthesis of nucleoside 5′-phosphosulfates (NPS) from nucleoside 5′-phosphorimidazolides and sulfate bis(tributylammonium) salt. Using this method we obtained various NPS with yields ranging from 70-90%, including adenosine 5′-phosphosulfate (APS) and 2′,3′-cyclic precursor of 3′-phosphoadenosine 5′-phosphosulfate (PAPS), which are the key intermediates in the assimilation and metabolism of sulfur in all living organisms.