5648-17-9

Basic information

• Product Name: 3,7-dibenzyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one
• Synonyms: 3,7-Diazabicyclo[3.3.1]nonan-9-one, 1,5-dimethyl-3,7-bis(phenylmethyl)-; 3,7-Dibenzyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one; 3,7-Dibenzyl-1,5-dimethyl-3,7-diaza-bicyclo[3.3.1]nonan-9-one
• CAS NO: 5648-17-9
• Molecular Formula: C₂₃H₂₈N₂O
• Molecular Weight: 348.4812
• Mol File: 5648-17-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 469.7°C at 760 mmHg
• Flash Point: 186.9°C
• Density: 1.141g/cm³
• Vapor Pressure: 5.38E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 3,7-dibenzyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-dibenzyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one(5648-17-9)
• EPA Substance Registry System: 3,7-dibenzyl-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one(5648-17-9)

Safety Data

• Hazardous Substances Data: 5648-17-9(Hazardous Substances Data)

Upstream product

• 50479-11-3 (3-ethoxycarbonylpropyl)triphenylphosphonium bromide 

Relevant articles and documents

Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates

Pd0-catalyzed Mizoroki–Heck reactions traditionally exhibit poor reactivity with polysubstituted, unbiased alkenes. Intermolecular reactions with simple, all-carbon tetrasubstituted alkenes are unprecedented. Herein we report that pendant carboxylic acids, combined with bulky monophospine ligands on palladium, can direct the arylation of tri- and tetrasubstituted olefins. Quaternary carbons are established at high Fsp3 attached-ring junctures and the carboxylate directing group can be removed after coupling. Carboxylate directivity prevents over-arylation of the new, less substituted alkene, which can be diversified in subsequent reactions.