56517-30-7Relevant articles and documents
Synthetic method of 6-Bromoisovanillin
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Paragraph 0020; 0021; 0022; 0026; 0027, (2016/10/17)
The invention discloses a synthetic method of 6-Bromoisovanillin. The method comprises the steps of taking ethyl vanillin as a starting material, and preparing the 6-Bromoisovanillin through a methylation reaction, a bromination reaction and an acid decomposition reaction in sequence. After the bromination reaction is finished, first a reacted material is neutralized by using alkali liquor, and then excessive bromine is removed by using sodium thiosulfate. The acid decomposition reaction is first performed at a relatively low temperature, and then is performed at a relatively high temperature. The method provided by the invention takes the ethyl vanillin as the starting material, so the production cost is greatly reduced relative to that of expensive isovanillin. The yield of two steps of the methylation reaction and the bromination reaction can reach more than 95 percent, and more important, the reaction yield of removing ethyl by acid decomposition can reach about 75 percent, so that the total reaction yield can reach 70 percent or more than 70 percent.