565174-22-3

Basic information

• Product Name: 4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: BUTTPARK 25\07-92;4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL;AKOS TOT-0023;AKOS BBS-00004212;4-amino-5-(2-fluorophenyl)-2H-1,2,4-triazole-3-thione;T0517-1414;ZINC03361036
• CAS NO: 565174-22-3
• Molecular Formula: C₈H₇FN₄S
• Molecular Weight: 210.23
• Mol File: 565174-22-3.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(565174-22-3)
• EPA Substance Registry System: 4-AMINO-5-(2-FLUORO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL(565174-22-3)

Safety Data

• Hazardous Substances Data: 565174-22-3(Hazardous Substances Data)

Upstream product

• 166093-16-9 C₈H₆FN₂OS₂^(1-)*K⁽¹⁺⁾ 
• 446-24-2 2-fluorobezohydrazide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 203268-62-6 5-(2-fluorophenyl)-1,3,4-oxadiazole-2-thiol 
• 445-29-4 o-fluoro-benzoic acid 
• 394-35-4 methyl 2-fluorobenzoate 
• 75-15-0 carbon disulfide 
• 2231-57-4 Thiocarbohydrazide 

Downstream Products

• 1172617-28-5 6-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(2-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1172617-29-6 6-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-3-(2-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1172617-30-9 3-(2-fluorophenyl)-6-(4-methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1172617-31-0 (R)-3-(2-fluorophenyl)-6-(4-methoxy-3-(tetrahydrofuran-3-yloxy)phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 579441-23-9 6-(3,4-dimethoxyphenyl)-3-(2-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1146943-15-8 3-(2-fluorophenyl)-6-(phenoxymethyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 

Relevant articles and documents

Novel 1,2,4-Triazole Compound And Pharmaceutical Composition For Inhibiting Urease Comprising The Same

The present invention provides a 1,2,4-triazole compound represented by formula 1 or a pharmaceutically acceptable salt thereof: In formula 1, R is a methoxy group, a fluoro or bromo group, Y is a thiophenyl group, a pyroyl group, an ethyl phenyl group, a

Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors

A series of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases were synthesized through Mannich reaction with high yields. Their structures were confirmed by means of IR, 1H NMR, 13C NMR and elemental analysis. The preliminary bioassay indicated that compounds 7g, 7h and 7l exhibited potent in vitro inhibitory activities against ketol-acid reductoisomerase (KARI) with Ki value of (0.38 ± 0.25), (6.59 ± 2.75) and (8.46 ± 3.99) μmol/L, respectively, and were comparable with IpOHA. They could be new KARI inhibitors for follow-up research. Some of the title compounds also exhibited obvious herbicidal activities against Echinochloa crusgalli and remarkable in vitro fungicidal activities against Physalospora piricola and Rhizoctonia cerealis. The SAR of the compounds were analyzed, in which the molecular docking revealed the binding mode of 7g with the KARI, and the 3D-QSAR results provided useful information for guiding further optimization of this kind of structures to discover new fungicidal agents towards Rhizoctonia cerealis.

1,2,4-Triazolethione derivative containing (hetero)aryl group and piperazine, and preparation method and application thereof

The invention discloses a 1,2,4-triazolethione derivative containing a (hetero)aryl group and piperazine, and a preparation method and an application thereof. The synthesis method has the advantages of few reaction steps, simple and mild conditions, simple operation and high yield. The derivative has a structural formula represented by general formula I and general formula II, and R, R and R in the general formula I and the general formula II are as defined in claim 1. The above compounds have certain in vitro inhibition activity to cucumber fusarium wilt, Cercospora arachidicola Hori, Macrophoma kawatsukai, Altemaria solani, Fusarium graminearum, Rhizoctonia cerealis and other plant pathogens, and especially have high in vitro inhibition activity on the cucumber fusarium wilt, Cercospora arachidicola Hori, Macrophoma kawatsukai and Rhizoctonia cerealis. The compounds of the general formula I and general formula II simultaneously have rice KARI enzyme in vitro inhibition activity. The derivative is suitable for comprehensive control of fungus damages on various crops.