56521-72-3

Basic information

• Product Name: 2-methoxyethyl bromoacetate
• CAS NO: 56521-72-3
• Molecular Formula: C₅H₉BrO₃
• Molecular Weight: 197.0272
• Mol File: 56521-72-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 214.1°C at 760 mmHg
• Flash Point: 83.3°C
• Density: 1.469g/cm³
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: 2-methoxyethyl bromoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxyethyl bromoacetate(56521-72-3)
• EPA Substance Registry System: 2-methoxyethyl bromoacetate(56521-72-3)

Safety Data

• Hazardous Substances Data: 56521-72-3(Hazardous Substances Data)

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 109-86-4 2-methoxy-ethanol 
• 79-08-3 bromoacetic acid 
• 598-21-0 2-Bromoacetyl bromide 
• 110-71-4 1,2-dimethoxyethane 

Downstream Products

• 3785-34-0 ethane-1,2-diyl bis(2-bromoacetate) 
• 42064-17-5 dioxa-3,6 heptanoate methoxy-2 ethyle 

Relevant articles and documents

Novel ibuprofen prodrugs with improved pharmacokinetics and non-ulcerogenic potential

In the present study, we evaluated the anti-inflammatory activity with pharmacokinetic, ulcerogenic properties of various synthesized prodrugs of ibuprofen in experimental animals. Prodrugs 2, 6, 9, 10, 12, and 14 were found to possess significant anti-inflammatory activity with almost non-ulcerogenic potential than standard drug ibuprofen 1a in both normal and inflammation-induced rats. Metabolic stability of prodrugs 2, 6, 9, 10, 12, and 14 were also studied in rat liver microsomes and oral bioavailability was determined by estimating area under curve (AUC) and plasma concentration of these prodrugs at various time intervals. The experimental findings elicited higher AUC and plasma concentration at 1 and 2 h indicating improved oral bioavailability as compared to parent ibuprofen. These prodrugs are found to have least gastric ulceration with retain anti-inflammatory activity observed in experimental animals. Therefore, present experimental findings demonstrated significant improvement of various pharmacokinetic properties with least ulcerogenic potential of ester prodrugs of ibuprofen an anti-inflammatory agent

Biodegradable, non-bactericidal oxygen-functionalised imidazolium esters: A step towards 'greener' ionic liquids

A series of imidazolium ionic liquids was prepared and screened against 7 bacterial strains. The incorporation of ether groups into the ester side-chain significantly reduced the toxicity compared with alkyl ester derivatives. Biodegradation data are also presented for 15 of the ionic liquids - including 6 examples which can be classed as readily biodegradable.

Bromoacetyl bromide: A versatile and selective cleaving agent for ethers and acetals

It is shown that bromoacetyl bromide can be utilized for the selective cleavage of ethers and acetals in high yields. With cyclic ethers and acetals as starting materials, cleavage products are produced with two strategically positioned bromo substituents which may be exploited for selective extention of the carbon chain.