56535-85-4

Basic information

• Product Name: 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE
• Synonyms: 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE;1-phenyl-tetrahydropyrimidin-2(1H)-one
• CAS NO: 56535-85-4
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Product Categories: pharmacetical
• Mol File: 56535-85-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 376.3 °C at 760 mmHg
• Flash Point: 181.4 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 7.34E-06mmHg at 25°C
• Refractive Index: 1.56
• CAS DataBase Reference: 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE(56535-85-4)
• EPA Substance Registry System: 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE(56535-85-4)

Safety Data

• Hazardous Substances Data: 56535-85-4(Hazardous Substances Data)

Usage

General Description

1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE is a chemical compound with a molecular formula C11H13NO. It is a heterocyclic compound that contains a pyrimidin-2-one moiety, and a phenyl group attached at the first position. 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE is used as a building block in organic synthesis, and it has applications in the pharmaceutical and agrochemical industries. It can be used in the production of various drugs and other organic compounds. 1-PHENYL-TETRAHYDRO-2(1H)-PYRIMIDINONE has potential biological activities and can be used as a precursor for the synthesis of molecules with pharmacological properties.

InChI:InChI=1/C10H12N2O/c13-10-11-7-4-8-12(10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,13)

Upstream product

• 5259-97-2 [1,3]oxazinan-2-one 
• 62-53-3 aniline 
• 117784-31-3 (3-Phenylamino-propyl)-carbamic acid ethyl ester 
• 4742-01-2 N-(3-aminopropyl)aniline 
• 3420-63-1 N-(3-Chloropropyl)-N'-phenylurea 
• 17758-13-3 1-phenyl-2(1H)-pyrimidinone 

Downstream Products

• 1350900-47-8 1-(5-([1,4'-bipiperidin]-1'-yl)-1,3,4-thiadiazol-2-yl)-3-phenyltetrahydropyrimidin-2(1H)-one 
• 1311946-41-4 4-(tetrahydro-2-oxopyrimidin-1(2H)-yl)benzene-1-sulfonyl chloride 
• 1311946-34-5 4-fluorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-32-3 4-chlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-30-1 4-tolyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-29-8 3,4,5-trimethoxyphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-28-7 3-fluorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-27-6 3-methoxyphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-26-5 3-tolyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-24-3 2,4,6-trichlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-22-1 2,4,5-trichlorophenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-20-9 2,4-dimethylphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-19-6 2-propylphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 
• 1311946-17-4 2-ethylphenyl 4-[tetrahydro-2-oxopyrimidin-1(2H)-yl]benzenesulfonate 

Relevant articles and documents

Design, synthesis, biological evaluation, and Structure - Activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4

Sixty-one phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs) and 13 of their tetrahydro-2-oxopyrimidin-1(2H)-yl analogues (PPB-SOs) were prepared and biologically evaluated. The antiproliferative activities of PIB-SOs on 16 cancer cell lines are

COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS

Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.

New substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with α2-adrenoceptor antagonist activity

The emergence of a novel theory concerning the role of noradrenaline in the progression and the treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases has provided a new impetus toward the discovery of novel compounds acting at α2-adrenoceptors. A series of substituted 1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl derivatives bearing an amide, urea, or imidazolidinone moiety was studied. Some members of this series of compounds proved to be potent α2-adrenoceptor antagonists with good selectivity versus α1-adrenergic and D2-dopamine receptors. Particular emphasis is given to compound 33g which displays potent α2-adrenoceptor binding affinity in vitro and central effects in vivo following oral administration.