565446-44-8

Basic information

• Product Name: 1H-Imidazole-4-propanenitrile, 1-(triphenylmethyl)-
• CAS NO: 565446-44-8
• Molecular Formula: C25H21N3
• Molecular Weight: 363.462
• Mol File: 565446-44-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-4-propanenitrile, 1-(triphenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-propanenitrile, 1-(triphenylmethyl)-(565446-44-8)
• EPA Substance Registry System: 1H-Imidazole-4-propanenitrile, 1-(triphenylmethyl)-(565446-44-8)

Safety Data

• Hazardous Substances Data: 565446-44-8(Hazardous Substances Data)

Upstream product

• 33769-07-2 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole 
• 76-83-5 trityl chloride 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 154312-79-5 1-trityl-4-(2-cyanoethyl)imidazole 

Downstream Products

• 195053-89-5 4-(3-aminopropyl)-1-(triphenylmethyl)-imidazole 
• 565446-69-7 N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-67-5 N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-65-3 N-benzoyl-N'-[3-(5-oxy-4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-64-2 N-benzoyl-N'-[3-(4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-60-8 N-benzoyl-N'-[2-(4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-54-0 N-benzoyl-N'-(3-hydroxypropyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine 
• 565446-52-8 N-benzoyl-N'-(2-hydroxyethyl)-N-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}guanidine 
• 565446-50-6 1-benzoyl-2-{3-[(1-triphenylmethyl)-imidazol-4-yl]propyl}-O-phenylisourea 
• 565446-69-7 N-[3-(4-benzenesulfonyl-5-oxy-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-67-5 N-[3-(4-benzenesulfonyl-furazan-3-yloxy)-propyl]-N'-benzoyl-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-65-3 N-benzoyl-N'-[3-(5-oxy-4-phenyl-furazan-3-yloxy)-propyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 
• 565446-62-0 N-benzoyl-N'-[2-(5-oxy-4-phenyl-furazan-3-yloxy)-ethyl]-N''-[3-(1-trityl-1H-imidazol-4-yl)-propyl]-guanidine 

Relevant articles and documents

H3 receptor ligands: New imidazole H3-antagonists endowed with NO-donor properties

Synthesis and pharmacological properties of a group of compounds obtained by coupling the H3-antagonist SKF 91486 with the NO-donor 3-phenylfuroxan-4-yloxy and 3-benzenesulfonylfuroxan-4-yloxy moieties, as well as with the corresponding furazan analogues, devoid of NO-donating properties, are reported. All the products were tested for their H3-antagonistic and H2-agonistic properties on electrically-simulated guinea-pig ileum segments and guinea-pig papillary muscle, respectively. All the synthesised compounds displayed good H3-antagonistic properties (pA2 range 7.02-8.49) while behaving only as weak partial H2-agonists. Derivative 28, the best NO-donor of the series, was able to trigger a dual NO-dependent muscle relaxation and H3-antagonistic effect on guinea-pig illeum.

AN EXPEDITIOUS SYNTHESIS OF 4(5) IMIDAZOLE

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