565453-39-6

Basic information

• Product Name: Vildagliptin iMpurity K
• Synonyms: Vildagliptin Impurity A;Vildagliptin Amide Impurity;(S)-1-[2-(-3-hydroxy-adaMantan-1-ylaMino)-acetyl]-pyrrolidine-2-carboxylic acid;Vildagliptin iMpurity K;(2S)-1-[2-[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxamide;1-(2-((3-hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carboxamide
• CAS NO: 565453-39-6
• Molecular Formula: C17H26N2O4
• Molecular Weight: 322.39934
• Mol File: 565453-39-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 94-96 °C
• Boiling Point: 585.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• PKA: 15.05±0.40(Predicted)
• CAS DataBase Reference: Vildagliptin iMpurity K(CAS DataBase Reference)
• NIST Chemistry Reference: Vildagliptin iMpurity K(565453-39-6)
• EPA Substance Registry System: Vildagliptin iMpurity K(565453-39-6)

Safety Data

• Hazardous Substances Data: 565453-39-6(Hazardous Substances Data)

Usage

Uses

N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).

Upstream product

• 1044676-63-2 vildagliptin 
• 702-82-9 3-aminoadamantan-1-ol 
• 768-94-5 1-Adamantanamine 
• 38074-72-5 (S)-1-(2-chloroacetyl)pyrrolidine-2-carboxylic acid methyl ester 
• 147-85-3 L-proline 
• 1032564-18-3 [(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid 
• 7531-52-4 L-prolinamide 
• 214398-99-9 (S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide 

Relevant articles and documents

A preparation method of the peculiar smell degradation impurity

The invention discloses a method for preparing vildagliptin degradation impurities. The method comprises the following steps: dissolving vildagliptin I in a solvent, adding an alkali solution, heating to 30-100 DEG C and reacting for 1-10 hours to obtain vildagliptin amide II. The method is short in synthetic route, simple and high in operability; the product meeting quality standards can be easily obtained through simple purification.

NEW PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF VILDAGLIPTIN

A new process for the synthesis of vildagliptin a via a novel intermediate formed by salification of prolinamide with haloacetic acid.