565470-45-3

Basic information

• Product Name: 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
• Synonyms: 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
• CAS NO: 565470-45-3
• Molecular Weight: 353.331
• Mol File: 565470-45-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid(565470-45-3)
• EPA Substance Registry System: 2-(2-benzyloxycarbonyl-ethyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid(565470-45-3)

Safety Data

• Hazardous Substances Data: 565470-45-3(Hazardous Substances Data)

Upstream product

• 27019-47-2 β-alanine benzyl ester p-toluenesulfonate 
• 552-30-7 trimellitic Anhydride 

Downstream Products

• 610781-71-0 3-[1,3-dioxo-5-(4-pyrimidin-2-yl-piperazine-1-carbonyl)-1,3-dihydro-isoindol-2-yl]-propionic acid benzyl ester 
• 565470-52-2 3-{5-[2-(1H-benzoimidazol-2-yl)-ethylcarbamoyl]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-propionic acid benzyl ester 
• 565470-51-1 3-{5-[(1H-benzoimidazol-2-ylmethyl)-carbamoyl]-1,3-dioxo-1,3-dihydro-isoindol-2-yl}-propionic acid benzyl ester 

Relevant articles and documents

Synthesis of 5-carbonyl-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid integrin antagonists

The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa-e), which then hydrogenolyzed by 5% palladium-on-carbon to give target compounds (IVa-e).