566-35-8

Basic information

• Product Name: 11-ALPHA-HYDROCORTISONE
• Synonyms: Pregn-4-ene-11,17,21-triol-3,20-dione;EPI COMPOUND ''F'';EPI COMPOUND 'F';11-EPICORTISOL;11-EPIHYDROCORTISONE;11-ALPHA-HYDROCORTISONE;4-PREGNEN-11-ALPHA, 17,21-TRIOL-3,20-DIONE;4-PREGNEN-11ALPHA,17ALPHA,21-TETROL-3,20-DIONE
• CAS NO: 566-35-8
• Molecular Formula: C₂₁H₃₀O₅
• Molecular Weight: 362.46
• Mol File: 566-35-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 217-219 °C
• Boiling Point: 566.4°Cat760mmHg
• Flash Point: 310.4°C
• Appearance: /
• Density: 1.28g/cm³
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 12.47±0.70(Predicted)
• CAS DataBase Reference: 11-ALPHA-HYDROCORTISONE(CAS DataBase Reference)
• NIST Chemistry Reference: 11-ALPHA-HYDROCORTISONE(566-35-8)
• EPA Substance Registry System: 11-ALPHA-HYDROCORTISONE(566-35-8)

Safety Data

• Hazardous Substances Data: 566-35-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 566-35-8 differently. You can refer to the following data:
1. 11-Epihydrocortisone is an isomer of Hydrocortisone (H714615), a glucocorticord which functions primarily to increase blood sugar through gluconeogenesis, suppression of immune system and aid in fat, protein and carbohydrate metabolism.
2. 11-Epihydrocortisone (Hydrocortisone EP Impurity M) is an isomer of Hydrocortisone (H714615), a glucocorticord which functions primarily to increase blood sugar through gluconeogenesis, suppression of immune system and aid in fat, protein and carbohydrate metabolism.

Upstream product

• 152-58-9 C₂₁H₃₀O₄ 
• 152-58-9 Cortexolone 
• 50-23-7 HYDROCORTISONE 

Downstream Products

• 127182-47-2 11α,17,21-trihydroxy-5α-pregnane-3,20-dione 
• 906335-33-9 11α,17,21-trihydroxy-5β-pregnane-3,20-dione 
• 600-90-8 11α,17α,21-trihydroxypregna-1,4-diene-3,20-dione 
• 115362-15-7 21-acetoxy-17-hydroxy-11α-(toluene-4-sulfonyloxy)-pregn-4-ene-3,20-dione 
• 102030-55-7 3,20-bis(ethylenedioxy)-11α,17α,21-trihydroxypregn-5-ene 
• 10184-70-0 Anecortave 
• 7753-60-8 anecortave 
• 127-31-1 Fludrocortisone 
• 514-36-3 fludrocortisone acetate 
• 357-09-5 9α-Fluor-11β-hydroxy-3,17-dioxo-androsten-4 
• 79-60-7 9α-fluorocortisone 
• 29042-01-1 21-acetoxy-9-chloro-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 50733-54-5 21-acetoxy-9-bromo-11β,17-dihydroxy-pregn-4-ene-3,20-dione 
• 6635-85-4 21-acetoxy-11β,17-dihydroxy-9-methoxy-pregn-4-ene-3,20-dione 

Relevant articles and documents

Dehalogenation methodof 9-halogenated steroid compound and application

The invention provides a dehalogenation method of a 9-halogenated steroid compound and application, and relates to the technical field of chemical synthesis. The dehalogenation method of the 9-halogenated steroid compound comprises the following steps: reacting a compound I with a hydrogen donor and an azo radical initiator to obtain a 9-dehalogenated product compound II of the 9-halogenated steroid compound. According to the dehalogenation method of the 9-halogenated steroid compound, a hydrogen donor adopts one or a combination of more of hypophosphorous acid and hypophosphite, formic acid and formate, organic silicon hydride, hydrazine compounds or cyclohexene, and an initiator adopts an azo free radical initiator. Reagents such as chromium, divalent chromium salt, trivalent chromium salt or tributyltin hydride which are high in toxicity and cause serious pollution to the environment are not used in the reaction, the method is green and environmentally friendly, the synthesis process is simple, convenient and easy to implement, and the production applicability is improved.

MICROBIOLOGICAL HYDROXYLATION OF STEROIDS. IV. INFLUENCE OF THERMAL TREATMENT ON THE ENZYME ACTIVITY OF HYDROXYLATING CULTURES

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