56624-44-3Relevant articles and documents
An efficient protocol for the synthesis of β-substituted ethyl dithiocarbamates: A novel class of anti-cancer agents
Chaturvedi, Devdutt,Zaidi, Sadaf,Chaturvedi, Amit K.,Vaid, Shagun,Saxena, Ajit K.
, p. 1019 - 1025 (2017/11/10)
A novel one-pot method for the synthesis of β-substituted alkyl dithiocarbamates has been developed through die Michael addition reaction of dithiocarbamate anion to α,β-unsaturated activated olefins employing catalytic amount of benzyl trimethyl ammonium hydroxide (Triton-B). The reaction conditions are mild with extremely simple work-up procedures than the reported methods, and afford high yields (82-98%) of the desired products. All the synthesized compounds (1-16) have been evaluated for in vitro anti-cancer activity using various kinds of cancer cell lines such as lung, colon, cervical, neuroblastoma, liver and ovary employing different kinds of standard anticancer drugs such as 5-fluorouracil, mitomycin C, paclitaxel, aldriamycin, etc. using stock solution (2 × 10-2 M) prepared in DMSO and further dilution has been carried out with medium. In vitro cytotoxicity against human cancer cell lines is determined using sulphorhodamine-B assay. Out of the series of compounds evaluated, most of these compounds such as compounds 2,3,4,5,9,10,11,12,13,14,15,16 display more than 50% growth inhibition at 1 × 10-5 M concentration.
An efficient synthesis of aryldithiocarbamic acid esters from Michael addition of electron-deficient alkenes with arylamines and CS2 in solid media alkaline Al2O3
Xia, Shuai,Wang, Xin,Ge, Ze-mei,Cheng, Tie-ming,Li, Run-tao
experimental part, p. 1005 - 1009 (2009/04/10)
An efficient synthesis of dithiocarbamic acid esters from Michael addition of electron-deficient alkenes with arylamines and CS2 in solid media alkaline Al2O3 was presented. This method was suitable for a wide range of amines and a variety of Michael receptors. Specially, a series of aryldithiocarbamic acid esters was obtained from arylamines through this method. The protocol offers clean reactions and high yields with simple experimental procedures. Besides, the alkaline Al2O3 could be reused.
Waste-free and environment-friendly uncatalyzed synthesis of dithiocarbamates under solvent-free conditions
Azizi, Najmedin,Ebrahimi, Forogh,Aakbari, Elham,Aryanasab, Fezzeh,Saidi, Mohammad R.
, p. 2797 - 2800 (2008/02/12)
A mild, convenient, and practical one-pot procedure for the direct synthesis of dithiocarbamates has been developed by condensation of amines, CS2, and a Michael acceptor, under solvent-free conditions at room temperature in good to excellent yields. Georg Thieme Verlag Stuttgart.
