5663-56-9

Basic information

• Product Name: 3,4-DIMETHOXYPHENYLACETAMIDE
• Synonyms: 3,4-DIMETHOXYPHENYLACETAMIDE;HOMOVERATRAMIDE;3,4-dimethoxy-benzeneacetamid;3,4-dimethoxybenzeneacetamide;2-(3,4-dimethoxyphenyl)acetamide;2-(3,4-dimethoxyphenyl)ethanamide;NSC 73172
• CAS NO: 5663-56-9
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• EINECS: 227-119-2
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 5663-56-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 170-171℃
• Boiling Point: 375.5 °C at 760 mmHg
• Flash Point: 200.2 °C
• Appearance: /
• Density: 1.141
• Vapor Pressure: 7.77E-06mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 2-8°C
• PKA: 16.03±0.40(Predicted)
• CAS DataBase Reference: 3,4-DIMETHOXYPHENYLACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYPHENYLACETAMIDE(5663-56-9)
• EPA Substance Registry System: 3,4-DIMETHOXYPHENYLACETAMIDE(5663-56-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 5663-56-9(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 548, 1950 DOI: 10.1021/jo01149a016

InChI:InChI=1/C10H13NO3/c1-13-8-4-3-7(6-10(11)12)5-9(8)14-2/h3-5H,6H2,1-2H3,(H2,11,12)

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 79-37-8 oxalyl dichloride 
• 25844-67-1 2-(3,4-dimethoxyphenyl)-3-oxo-3-phenylpropanenitrile 
• 5703-21-9 3,4-dimethoxyphenylacetaldehyde 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 

Downstream Products

• 115933-04-5 1,4-dihydro-1-[(3,4-dimethoxyphenyl)acetyl]4,4-dimethylpyridine 
• 2024-83-1 veratronitrile 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 78222-21-6 3,4-dimethoxy-N-hydroxymethylphenylacetamide 
• 73954-34-4 N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide 
• 148849-67-6 ivabradine hydrochloride 
• 1086026-31-4 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 
• 148870-57-9 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one 
• 85175-59-3 3-(3-chloropropyl)-1,3-dihydro-7,8-dimethoxy-2H-3-benzazepine-2-one 
• 1429633-42-0 4-chloro-6-(5-(3,4-dimethoxybenzyl)-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine 
• 1429635-39-1 4-(5-(3,4-dimethoxybenzyl)-1H-1,2,4-triazol-1-yl)-2-methyl-6-((5-methylpyridin-2-yl)ethyl)pyrimidine 
• 1429635-38-0 4-(5-(3,4-dimethoxybenzyl)-1H-1,2,4-triazol-1-yl)-2-methyl-6-((5-methylpyridin-2-yl)ethynyl)pyrimidine 
• 861393-66-0 N-(1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide 
• 861393-99-9 N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-2-(3,4-dimethoxyphenyl)acetamide 

Relevant articles and documents

Method for synthesizing α - isopropyl -3 and 4 -methoxyacetonitrile

The invention belongs to the technical field of organic synthesis, and particularly discloses a synthesis method α - isopropyl -3 and 4 -methoxyacetonitrile. To 3, 4 - dimethoxyphenyl acetic acid as a raw material, 2 - (3, 4 - dimethoxyphenyl) acetamide is formed through acylation reaction, and 3, 4 -methoxyphenyl acetonitrile are obtained by dehydration, and α - isopropyl -3 and 4 -methoxyacetonitrile are formed by alkylation reaction. The starting materials are cheap and easily available. The method avoids the use of highly toxic crisis reagents, is mild in reaction conditions, simple in post-treatment, short in synthetic route and high in yield.

Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations

A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.

Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.