56642-55-8

Basic information

• Product Name: C₂₄H₁₈N₂O₂
• Synonyms: C₂₄H₁₈N₂O₂
• CAS NO: 56642-55-8
• Molecular Weight: 366.419
• Mol File: 56642-55-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₂₄H₁₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₁₈N₂O₂(56642-55-8)
• EPA Substance Registry System: C₂₄H₁₈N₂O₂(56642-55-8)

Safety Data

• Hazardous Substances Data: 56642-55-8(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 21487-45-6 1,3-diphenyl-4-formylpyrazole 

Downstream Products

• 56642-61-6 2-(1,3-diphenyl-1H-pyrazol-4-yl)-3-hydroxy-chromen-4-one 
• 1351791-29-1 1-(3-(E)-(2-(1,3-diphenyl-1H-pyrazol-4-yl)vinyl)benzofuran-2-yl)ethanone 
• 17647-21-1 1,3-diphenyl-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

Synthesis of benzoxazepine derivatives from pyrazole-chalcone via a simple and convenient protocol using basic alumina as solid support

In the present study a series of novel benzoxazepine (5a-h) derivatives were synthesized by the thermal cyclization reaction of various pyrazole-chalcones (3a-h) with 2-aminophenol, by conventional heating and microwave irradiation (180 W) in solvent-free conditions in short reaction times (9-12 min), giving high yields of products (80-88%). The homogeneity of all the newly synthesized compounds has been checked by TLC. Their IR, NMR, ESI-mass spectral data and elemental analysis are in accord with the assigned structure. The title compounds were evaluated for their antibacterial activity against Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, and Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli. Compounds 3c, 3h, 5b, 5c, 5g and 5h were found to show good antibacterial activity when compared with that of standard drug Ampicillin. Furthermore, the same library of compounds were evaluated for antifungal activity against Aspergillus nigerzeae, Penicillium italicum and Fusarium oxysporum using Grieseofulvin as standard drug. The results of the above studies show that the compounds 3b, 3c, 3e, 3h, 5a, 5c, 5g and 5h showed good antifungal activity against all the tested organisms.

Solvent free microwave assisted synthesis of Substituted 1-(3-((E)-2-(3-(aryl)-1-phenyl-1h-pyrazol-4-yl) vinyl)-benzofuran-2-yl) ethanones

Substituted 1-(2-hydroxy phenyl)-3-[3-(4-aryl)-1-phenyl-1 H-pyrazol-4-yl]-propenones (la-h) have efficiently been synthesized by the condensation of 3-aryl-1-phenyl-pyrazole-4-carbaldehydes with 2-hydroxy acetophenones using basic alumina under solvent fr

Synthesis and antifungal activity of some new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones

Seven new 3-hydroxy-2-(1-phenyl-3-aryl-4-pyrazolyl) chromones 4a-g have been synthesized by the oxidation of 2-hydroxychalcone analogues of pyrazole 3a-g with hydrogen peroxide (H2O2) in KOH-MeOH by Algar Flynn Oymanda (AFO) reaction