56703-34-5

Basic information

• Product Name: Benzenepropanoic acid, 4-(hydroxymethyl)-
• CAS NO: 56703-34-5
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol File: 56703-34-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 4-(hydroxymethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 4-(hydroxymethyl)-(56703-34-5)
• EPA Substance Registry System: Benzenepropanoic acid, 4-(hydroxymethyl)-(56703-34-5)

Safety Data

• Hazardous Substances Data: 56703-34-5(Hazardous Substances Data)

Upstream product

• 56703-33-4 β-(p-chloromethylphenyl)propionic acid 
• 66885-68-5 (E)-p-formylcinnamic acid 
• 23359-08-2 4-formylcinnamic acid 
• 124-38-9 carbon dioxide 
• 1074-61-9 (4-vinyl-phenyl)-methanol 
• 590-29-4 potassium formate 
• 1075-49-6 4-ethenylbenzoic acid 
• 115974-97-5 methyl (E)-4-carboxyl cinnamate 
• 141286-90-0 methyl (E)-3-(4-(hydroxymethyl)phenyl)acrylate 
• 619-66-9 4-Carboxybenzaldehyde 
• 1592-20-7 4-Vinylbenzyl chloride 
• 283153-64-0 methyl 3-(4-(hydroxymethyl)phenyl)propanoate 

Downstream Products

• 34961-64-3 4-formyldihydrocinnamic acid 
• 38628-53-4 3-<4-(hydroxymethyl)phenyl>propanol 
• 1018674-58-2 cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-2-carboxylate 
• 1018674-56-0 3-[4-({4-[(benzyloxy)carbonyl]-3-[(cyclopentyloxy)carbonyl]piperazin-1-yl}methyl)phenyl]propanoic acid 
• 1018674-57-1 1-benzyl 2-cyclopentyl 4-(4-{3-[(1-isobutoxyethoxy)amino]-3-oxopropyl}benzyl)piperazine-1,2-dicarboxylate 
• 875150-46-2 3-[4-(3-hydroxy-propyl)-phenyl]-1-((1aS,5aR)-1,1,2-trimethyl-1,1a,5,5a-tetrahydro-3-thia-cyclopropa[a]pentalen-4-yl)-propan-1-one 
• 81121-62-2 p-(3-hydroxypropyl)-benzaldehyde 
• 56703-35-6 ethyl 3-[4-(bromomethyl)phenyl]propanoate 
• 66012-46-2 3-propionic acid 2,4,5-trichlorophenyl ester 
• 77284-27-6 3-propionic acid 2,4,5-trichlorophenyl ester 
• 77284-26-5 3-propionic acid 2,4,5-trichlorophenyl ester 
• 77284-25-4 3-propionic acid 2,4,5-trichlorophenyl ester 
• 66012-47-3 2,4,5-trichlorophenyl 3-(p-hydroxymethylphenyl)propionate 

Relevant articles and documents

Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes

Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.

Ligand-Controlled Regioselective Hydrocarboxylation of Styrenes with CO2 by Combining Visible Light and Nickel Catalysis

The ligand-controlled Markovnikov and anti-Markovnikov hydrocarboxylation of styrenes with atmospheric pressure of CO2 at room temperature using dual visible-light-nickel catalysis has been developed. In the presence of neocuproine as ligand, the Markovnikov product is obtained exclusively, while employing 1,4-bis(diphenylphosphino)butane (dppb) as the ligand favors the formation of the anti-Markovnikov product. A range of functional groups and electron-poor, -neutral, as well as electron-rich styrene derivatives are tolerated by the reaction, providing the desired products in moderate to good yields. Preliminary mechanistic investigations indicate the generation of a nickel hydride (H-NiII) intermediate, which subsequently adds irreversibly to styrenes.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.