56795-65-4Relevant articles and documents
Synthesis method for pharmaceutically acceptable salt of alkylhydrazine
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Paragraph 0037; 0048; 0055; 0056, (2017/08/28)
The invention discloses a synthesis method for pharmaceutically acceptable salt of alkylhydrazine. According to the method, with hydrazine hydrate and BOC anhydride as starting raw materials, BOC hydrazine is synthesized firstly, then alkyl compounds are added in, BOC alkylhydrazine is obtained, finally BOC is removed, and the pharmaceutically acceptable salt of the corresponding alkylhydrazine is obtained in a conversion manner. According to the synthesis method, the raw materials for use are low in price and cost and easy to obtain. The synthesis method is short in synthesis route and high in yield, the obtained product is high in chemical purity, special production equipment is not needed for all reactions, and obtained intermediates and the final product do not need column chromatography and crystallization and purification.
1,1,4,4,-TETRAALKYLAMIDAZINES. SYNTHESIS OF MONOALKYLHYDRAZINES
Zelenin, K. N.,Khrustalev, V. A.,Sergutina, V. P.
, p. 244 - 247 (2007/10/02)
A series of 1,1,4,4,-tetraalkylamidazines were synthesized.Their IR, UV, and 1H and 13C NMR spectra were investigated, and the characteristics of their stereochemical structure are discussed.Amidazines are alkylated by the action of alkyl iodides at the imine nitrogen atom.Alkaline cleavage of the alkyl iodide derivatives is a method for the production of monoalkylhydrazines.