56824-22-7

Basic information

• Product Name: 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride
• Synonyms: 2-(2-CHLOROETHYL)-N-METHYL-PYRROLIDINE;2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride;2-(2-CHLOROETHYL)-1-METHYLPYRROLIDINE HYDROCHLORIDE;2-(2-CHLOROETHYL)-1-METHYLPYRROLLDINE HYDROCHLORIDE;2-(2-CHLOROETHYL)-1-METHYL PYRROLIDINE HCL;2-(2-CHLOROETHYL)-N-METHYL-PYRROLIDINE HCL;N-methyl-2-(2-chloroethyl)pyrrolidine;2-(2-CHLOROETHYL)-N-METHYL-PYRROLIDINE =98%
• CAS NO: 56824-22-7
• Molecular Formula: C7H15Cl2N
• Molecular Weight: 184.11
• EINECS: 260-395-2
• Product Categories: PyrrolidinesHeterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrrolidines;Building Blocks;C4 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 56824-22-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-102 °C(lit.)
• Boiling Point: 181.5 °C at 760 mmHg
• Flash Point: 63.6 °C
• Appearance: light liquids
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• BRN: 6148386
• CAS DataBase Reference: 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride(56824-22-7)
• EPA Substance Registry System: 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride(56824-22-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: QE0175000
• Hazardous Substances Data: 56824-22-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 56824-22-7 differently. You can refer to the following data:
1. 2-(2-Chloroethyl)-N-methyl-pyrrolidine hydrochloride is an intermediate used in the synthesis of reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxcity.
2. 2-(2-Chloroethyl)-1-methylpyrrolidine hydrochloride was used in the synthesis of N-[2-(1-methylpyrrolidin-2-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl) amide. It was used as reagent during the synthesis of 1-methyl-2-[2-[2-(2-phenylethyl)phenoxy]ethyl]pyrrolidine hydrochlochloride.

InChI:InChI=1/C7H14ClN.ClH/c1-9-6-2-3-7(9)4-5-8;/h7H,2-6H2,1H3;1H

Upstream product

• 56502-01-3 (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine 
• 67004-64-2 2-(1-methyl-2-pyrrolidine)ethanol 
• 1352748-96-9 (S)-ethyl 2-(2-hydroxyethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 60307-26-8 R(+)-1-methyl-2-(2-hydroxyethyl)pyrrolidine 
• 61810-78-4 (-)-2-((S)-1-methylpyrrolidin-2-yl)ethanol 

Relevant articles and documents

Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1 H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors

Neuronal nitric oxide synthase (nNOS) inhibitors are effective in preclinical models of many neurological disorders. In this study, two related series of compounds, 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4- tetrahydroquinoline, containing a 6-substituted thiophene amidine group were synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). A structure-activity relationship (SAR) study led to the identification of a number of potent and selective nNOS inhibitors. Furthermore, a few representative compounds were shown to possess druglike properties, features that are often difficult to achieve when designing nNOS inhibitors. Compound (S)-35, with excellent potency and selectivity for nNOS, was shown to fully reverse thermal hyperalgesia when given to rats at a dose of 30 mg/kg intraperitonieally (ip) in the L5/L6 spinal nerve ligation model of neuropathic pain (Chung model). In addition, this compound reduced tactile hyperesthesia (allodynia) after oral administration (30 mg/kg) in a rat model of dural inflammation relevant to migraine pain.

Asymmetric synthesis of H1 receptor antagonist (R,R)-clemastine

The first asymmetric synthesis of (R,R)-clemastine (1) has been accomplished by the coupling of (R)-tertiary alcohol 2 and (R)-chloroethylpyrrolidine 3 via O-alkylation. (R)-Tertiary alcohol 2 was synthesized by stereoselective alkylation of chiral α-benz

SUBSTITUTED BENZHYDRYLETHERS

Disclosed herein are substituted benzhydrylethers of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of their use thereof.