5691-08-7

Basic information

• Product Name: 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE
• CAS NO: 5691-08-7
• Molecular Formula: C₁₄H₁₀N₂O
• Molecular Weight: 222.24
• Mol File: 5691-08-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 480.9 °C at 760 mmHg
• Flash Point: 242.3 °C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 2.09E-09mmHg at 25°C
• Refractive Index: 1.72
• CAS DataBase Reference: 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE(5691-08-7)
• EPA Substance Registry System: 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE(5691-08-7)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 5691-08-7(Hazardous Substances Data)

Usage

General Description

2-Pyridin-2-yl-1H-indole-3-carbaldehyde is a chemical compound with the molecular formula C14H10N2O. It is a derivative of indole, and it is classified as an aldehyde due to the presence of the carbaldehyde functional group. 2-PYRIDIN-2-YL-1H-INDOLE-3-CARBALDEHYDE is commonly used in the synthesis of pharmaceuticals and organic materials due to its unique chemical properties. Its aromatic ring structure and functional groups make it a versatile building block for the creation of various organic compounds. Additionally, it has been studied for its potential biological activities and applications in the field of medicinal chemistry.

InChI:InChI=1/C14H10N2O/c17-9-11-10-5-1-2-6-12(10)16-14(11)13-7-3-4-8-15-13/h1-9,16H

Upstream product

• 13228-40-5 2-(2-pyridinyl)-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 
• 119910-45-1 2-bromo-1H-indole-3-carbaldehyde 
• 13737-05-8 2-trimethylstannylpyridine 

Relevant articles and documents

Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

A series of benzofuran-3-one indole phosphatidylinositol-3-kinases (PI3K) inhibitors identified via HTS has been prepared. The optimized inhibitors possess single digit nanomolar activity against p110α (PI3K-α), good pharmaceutical properties, selectivity versus p110γ (PI3K-γ), and tunable selectivity versus the mammalian target of rapamycin (mTOR). Modeling of compounds 9 and 32 in homology models of PI3K-α and mTOR supports the proposed rationale for selectivity. Compounds show activity in multiple cellular proliferation assays with signaling through the PI3K pathway confirmed via phospho-Akt inhibition in PC-3 cells.

Creation of new promoters for plant's root growth: its application for the syntheses of vulcanine and borreline, and for combating desertification at gobi desert in inner mongolia 1#

Abstract - Various new 2-substituted indole-3-carbaldehydes are prepared. Structurally related alkaloids, vulcanine and borreline, are synthesized as well. Among the compounds, 2-haloindole-3-carbaldehydes are found to be potent promoters of plant's root growth. Its successful preliminary application is reported for making Gobi desert in Inner Mongolia full of plant.