57-08-9 Usage
Chemical Properties
WHITE POWDER
Originator
Acexamic acid ,Flamma
Uses
Different sources of media describe the Uses of 57-08-9 differently. You can refer to the following data:
1. 6-Acetamidohexanoic acid is used after oral administration of an antiulcer agent, zinc acexamate (ZAC) for treatment of gastric ulcer or small bowel inflammation.
2. wound healing agent
Manufacturing Process
400 L of demineralized water, 5.0 kg of calcium hydroxide, and 155.0 kg
(1000 moles) of acetyl-caprolactame are introduced under stirring and at a
temperature of about 25°C into a 1000 L stainless double walled reactor.
The temperature is raised to 30°C. 75.0 kg of calcium hydroxide are
introduced stepwise in the form of successive amounts of 2.0 kg each in the
medium, under stirring and at a temperature adjusted and maintained 25°-
30°C through external cooling, in a manner such that the time required to
introduce into the reactor the whole amount of calcium hydroxide
approximates 1.5 h. When the stirring is stopped, the pH is about 7.5-7.8.
The obtained mixture is stirred continuously at a temperature of 30°C during
14 h. At the end of this operation the pH is again adjusted at a value 7.5-7.8.
The hydrolysate is filtered on a 60 x 60 pressfilter comprising 6 compartments
and equipped with fabrics of the polyester known under the designation
TERGAL which have been previously coated with a suspension of a cellulose
commercialized under the trademark SOLKA FLOX BW20. The duration of
filtration is of 1.5 h. 580 L of the filtrate are recovered and subjected to a
concentration under reduced pressure in an evaporator the volume of which is
of 750 L, at a distillation temperature ranging from 45°-50°C under a reduced
pressure of 10-15 Torr.
The operation is ran until concentration of the solution to 280 L, the
concentrated solution being then left standing. The crystallisation is already
considerable 2 h after the end of the operation of concentration.
Crystallisation is ended after 16-24 h.
The crystals are centrifuged at a speed of 700 revolutions/minute. The
centrifuged crystals of calcium acexamate are washed twice on the centrifuge
with 20 l of acetone. 107.0 kg of crystals are obtained, which are dried under
vacuum at 40°C. The 96.0 kg of dry calcium acexamate obtained are ground
and sifted.
Acexamic acid may be produced by treatment of the calcium acexamate with
HCl.
Therapeutic Function
Antifibrinolytic
Check Digit Verification of cas no
The CAS Registry Mumber 57-08-9 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 57-08:
(4*5)+(3*7)+(2*0)+(1*8)=49
49 % 10 = 9
So 57-08-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO3/c1-7(10)9-6-4-2-3-5-8(11)12/h2-6H2,1H3,(H,9,10)(H,11,12)/p-1
57-08-9Relevant articles and documents
Examination of the Aspirin Acetylation Site of Human Serum Albumin by 13C NMR Spectroscopy
Gerig, J. T.,Katz, K. E.,Reinheimer, J. D.,Sullivan, Glenn R.,Roberts, John D.
, p. 158 - 161 (1981)
Human serum albumin has been specifically acetylated using aspirin in which the methyl carbon of the acetyl group was enriched to 90percent 13C.A single resonance at 23.13 ppm downfield from tetramethylsilane was observed in 13C difference spectra obtained at both 25.2 and 45.3 MHz.Chemical shift studies of several model compounds suggest that this is the resonance position to be expected for an acetamide group exposed to solvent.The line width observed for the enriched methyl resonance is consistent with free rotation of the methyl group.
CXCR4-TARGETED DIAGNOSTIC AND THERAPEUTIC AGENTS WITH REDUCED SPECIES SELECTIVITY
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Page/Page column 64, (2020/05/07)
The present disclosure relates to imaging and endoradiotherapy of diseases involving chemokine receptor 4 (CXCR4). Provided are compounds which bind or inhibit hCXCR4 and mCXCR4 and furthermore carry at least one moiety which is amenable to labeling. Provided are also medical uses of such compounds.
Method for synthesizing hexanediamine by taking caprolactam as raw material
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Paragraph 0030; 0033; 0034; 0048; 0051; 0052, (2019/11/21)
The invention discloses a method for synthesizing hexanediamine by taking caprolactam as a raw material. The method comprises the following steps that (1) after the hexanediamine, alkali and water aremixed, heating reflux is conducted, and thus 6-amino-caproate is obtained; (2) the 6-amino-hexanoate obtained in the step (1) is introduced into an amino protecting group to protect an amino end group, then acid is added for neutralization to generate aminocaproic acid with the amino protecting group; (3) after a product obtained in the step (2) is dried, a dehydration catalyst for amide is added, a heating reaction is conducted in the presence of an ammonia source to convert a carboxylic acid group into a cyano group, and thus product nitrile is obtained; and (4) after the product nitrile obtained in the step (3) is extracted and purified, catalytic hydrogenation is conducted to generate corresponding amine, then the protecting group is removed, and thus a target product can be obtained.
