57043-01-3

Basic information

• Product Name: (+/-)-trans-2-amino-cyclopentane carboxylic acid
• CAS NO: 57043-01-3
• Molecular Weight: 129.159
• Mol File: 57043-01-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (+/-)-trans-2-amino-cyclopentane carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-trans-2-amino-cyclopentane carboxylic acid(57043-01-3)
• EPA Substance Registry System: (+/-)-trans-2-amino-cyclopentane carboxylic acid(57043-01-3)

Safety Data

• Hazardous Substances Data: 57043-01-3(Hazardous Substances Data)

Upstream product

• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 
• 136315-71-4 (±)-trans-2-((tert-butoxycarbonyl)amino)cyclopentanecarboxylic acid 
• 1560-11-8 cyclopent-1-enecarboxylic acid 

Downstream Products

• 119993-56-5 ethyl trans-2-amino-1-cyclopentanecarboxylate hydrochloride 
• 136237-68-8 N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-trans-2-aminocyclopentanecarboxylic acid methyl ester 
• 114745-58-3 {2-[((1S,2S)-2-Benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester 
• 135053-11-1 trans-2-aminocyclopentanecarboxamide 
• 61935-49-7 trans-2-carbobenzyloxyamino-1-cyclopentanecarboxylic acid 

Relevant articles and documents

Radical cyclization in heterocycle synthesis. Part 13: Sulfanyl radical addition-cyclization of oxime ethers and hydrazones connected with alkenes for synthesis of cyclic β-amino acids

A combination of sulfanyl radical addition-cyclization of the oxime ethers and hydrazones connected with alkenes and subsequent conversion of a phenylsulfanylmethyl group to a carboxyl group provides a novel method for the construction of the cyclic β-amino acids. Upon treatment with thiophenol in the presence of AIBN, the oxime ethers and hydrazones smoothly underwent sulfanyl radical addition-cyclization to give the 2-(phenylsulfanylmethyl)cycloalkylamine. This method was successfully applied to the practical synthesis of 2-aminocyclopentanecarboxylic acid and 4-amino-3-pyrrolidinecarboxylic acid.

A novel preparation of 2-aminocyclopentanecarboxamides

Different syntheses of cis- and trans-2-aminocyclopentanecarboxamides were studied. A convenient and effective method was devised for the preparation of cis-2-aminocyclopentanecarboxamide derivatives starting from the readily available 6-tert-butoxycarbon

An improved synthesis of enantiopure β-amino acids

An improved method for the preparation of both the enantiopure β-amino acids is presented. The diastereomer benzyl β-amino esters, obtained by stereoselective reduction of β-enamino esters, were separated and hydrogenolyzed to the free enantiopure β-amino acids.