57060-86-3

Basic information

• Product Name: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• Synonyms: 1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID METHYL ESTER;3-ISOQUINOLINECARBOXYLIC ACID, 1,2,3,4-TETRAHYDRO-, METHYL ESTER;AKOS B020563;AKOS BB-6889;METHYL 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLATE;ART-CHEM-BB B020563;1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid methyl ester ,95%
• CAS NO: 57060-86-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 57060-86-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 298 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.125 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate(57060-86-3)
• EPA Substance Registry System: Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate(57060-86-3)

Safety Data

• Hazardous Substances Data: 57060-86-3(Hazardous Substances Data)

Usage

General Description

Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate is a specific type of chemical compound classified within the tetrahydroisoquinoline family. It has a highly specific structure that follows its name: a cyclical arrangement with a methyl ester attached, that is derived from the isoquinoline alkaloid chemical group. While there is not much information about it, the tetrahydroisoquinoline group of compounds is notable for their presence in a variety of biological organisms and for their use in making other compounds in both pharmaceutical applications and organic chemistry research. The specific uses and properties of "Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate", however, may vary based on the exact arrangement and attachments of its structure.

Upstream product

• 67-56-1 methanol 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 63-91-2 L-phenylalanine 
• 144831-77-6 (S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoic acid 
• 150-30-1 Phenylalanine 

Downstream Products

• 27104-73-0 methyl isoquinoline-3-carboxylate 
• 63006-93-9 3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 4254-32-4 indan-2-carboxylic acid methyl ester 
• 189563-75-5 2-tert-butyl 3-methyl 3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate 

Relevant articles and documents

New four-component Ugi-type reaction. Synthesis of 3-methyl-1-oxo-1,3,4,6, 11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinoline-3-carboxamides

A small-sized library of novel 3,4,11,11a-tetrahydro-2H-pyrazino[1,2-b] isoquinolin-1(6H)-ones is synthesized. Key synthetic step is based on a new variant of Ugi four component reaction using bifunctional keto acids, amine and isocyanide as starting mate

NATURAL KILLER CELLS

This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of IMK cells by increasing the expression of specific transcription factors associated with NK cell production.

Gene delivery system

The invention discloses a preparation method of a gene nano-liposome carrier Isoquinoline-3-acyl-RGDV(IRV) and an IRV/STAT3-siRNA gene delivery system. The IRV/STAT3-siRNA gene delivery system is composed of liposome carriers IRV and STAT3-siRNA, protamine and calf thymus DNA in a proportion, and has slow release and targeting effects. The cell transfection efficiency, the in-vitro anti-tumor activity, and the gene silencing efficiency and a cell action mechanism on the mRNA level and the protein level of a compound are evaluated with the lung cancer A549 cell strain as a model, and the result shows the IRV/STAT3-siRNA gene delivery system has more excellent anti-tumor activity and gene silencing efficiency compared with control groups. According to the system, the anti-tumor activity of the IRV/STAT3-siRNA gene delivery system is evaluated with an S180 ascites tumor mouse as a model, and the result shows that a 100% IRV/STAT3-siRNA group has an anti-tumor effect.