5728-44-9Relevant articles and documents
PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERSAS AS AGONISTS OF G- PROTEIN COUPLED RECEPTOR 43 (GPR43)
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Page/Page column 204, (2011/07/07)
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs
Zhang, Penglie,Bao, Liang,Zuckett, Jingmei F.,Goldman, Erick A.,Jia, Zhaozhong J.,Arfsten, Ann,Edwards, Susan,Sinha, Uma,Hutchaleelaha, Athiwat,Park, Gary,Lambing, Joseph L.,Hollenbach, Stanley J.,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 983 - 987 (2007/10/03)
Anthranilamides 4 and 5 were designed and synthesized as selective and orally bioavailable factor Xa inhibitors. Structural modifications aimed at lowering their lipophilicity were performed at the central phenyl ring and at the S4 binding biphenyl region by incorporating water solublizing substituents. The resulting compounds (e.g., 7, 8, 14, 30a, and 32b) are highly potent in vitro, and show improved activity in human plasma-based thrombin generation assay.
PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS
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, (2008/06/13)
Compounds are provided having a piperazine or homopiperazine ring which are useful in the treatment of thrombosis.