5728-91-6Relevant articles and documents
Access to α-Cyano Carbonyls Bearing a Quaternary Carbon Center by Reductive Cyanation
Ren, Xinyi,Shen, Chaoren,Wang, Guangzhu,Shi, Zhanglin,Tian, Xinxin,Dong, Kaiwu
supporting information, p. 2527 - 2532 (2021/05/05)
Reductive cyanation of tertiary alkyl bromides using electrophilic cyanating reagent and zinc reductant was developed, providing various α-cyano ketones, esters, and carboxamides containing a nitrile-bearing all-carbon quaternary center in good to excellent yields under mild reaction conditions. The corresponding reaction mechanism involving in situ generated organozinc reagent and reactivity distinction was elucidated by density functional theory computation.
METHODS OF PREPARING a,?-UNSATURATED OR a-HALO KETONES AND ALDEHYDES
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Paragraph 0116; 0117; 0130; 0131; 0134; 0135, (2017/07/14)
Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of α,β-unsaturated or α-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile α,β-unsaturated or α-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.