573-20-6

Basic information

• Product Name: Menadiol diacetate
• Synonyms: 1,4-Naphthalenediol,2-methyl-,diacetate;4-naphthalenediol,2-methyl-diacetate;Adaprin;Davitamon-K;Davitamon-K-oral;Kapilin;Kapilon;Kativpowder
• CAS NO: 573-20-6
• Molecular Formula: C₁₅H₁₄O₄
• Molecular Weight: 258.27
• EINECS: 209-352-1
• Product Categories: Biochemistry;Vitamins;Vitamins and derivatives;Inhibitors
• Mol File: 573-20-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 113 °C
• Boiling Point: 361.52°C (rough estimate)
• Flash Point: 195.1 °C
• Appearance: /
• Density: 1.2105 (rough estimate)
• Vapor Pressure: 2.96E-06mmHg at 25°C
• Refractive Index: 1.4872 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water
• CAS DataBase Reference: Menadiol diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Menadiol diacetate(573-20-6)
• EPA Substance Registry System: Menadiol diacetate(573-20-6)

Safety Data

• RTECS: QJ5250000
• Hazardous Substances Data: 573-20-6(Hazardous Substances Data)

Usage

Uses

Vitamin K4, is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system.

InChI:InChI=1/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3

Upstream product

• 481-85-6 2-methyl-1,4-naphthohydroquinone 
• 108-24-7 acetic anhydride 
• 58-27-5 menadione 
• 861331-93-3 4-chloro-2-methylnaphthalen-1-ol 
• 17735-17-0 2,3,4,4-tetrachloro-2-methyl-3,4-dihydro-2H-naphthalen-1-one 
• 67-56-1 methanol 
• 7664-93-9 sulfuric acid 
• 67597-84-6 2-Methyl-1,4-naphthohydroquinone 
• 110327-29-2 4-acetoxy-2-methyl-1-naphthol 
• 108170-78-1 5,8-diacetoxy-6-methyl-1,4-dihydro-naphthalene 
• 64-19-7 acetic acid 

Downstream Products

• 2211-27-0 4-acetoxy-3-methyl-1-naphthol 
• 84-80-0 phytomenadione 
• 53772-20-6 1-benzyloxy-3-methylnaphthalen-4-yl acetate 

Relevant articles and documents

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition of in Situ Oxidation-Generated ortho-Quinone Methides and Aldehydes

An unprecedented chiral secondary amine-catalyzed formal [4 + 2] annulation of aldehydes and oxidation-generated β-unsubstituted o-QMs is reported. This asymmetric protocol allows direct functionalization of the benzylic C-H bonds and furnishes [4 + 2] cycloadducts, chromanols, with excellent enantioselectivity and in up to 92% yield. The usability of this approach was further demonstrated by the enantioselective synthesis of anticancer Rhinacanthins derivative NKPLS8.

A METHOD OF MAKING VITAMIN K1

This invention discloses a method of making vitamin K1. The mentioned method of making vitamin K1 comprises performing a first one-pot synthesis with base catalyst, performing a first hydrolysis, performing a substitution, and performing a second one-pot synthesis for oxidation reaction without using metal oxidant. The starting material of this invention is stable 2-methyl-1,4-naphthoquinone. Preferably, this invention provides a method of making vitamin K1 efficiently on simplifying the operation and decreasing the formation of side-product. More preferably, without the usage of metal residue in this invention results that the vitamin K1 is more safety for clinical application.

The regioselective synthesis of monomethoxynaphthylene diacetates

Methods for the conversion of 1,4,5-naphthalenetriols into the corresponding monomethoxy diacetates are described. All utilise the formation of peri-bridged intermediates.