5732-87-6

Basic information

• Product Name: cyclopentaneacetonitrile
• Synonyms: cyclopentaneacetonitrile;Einecs 227-241-6;Cyclopentylacetonitrile
• CAS NO: 5732-87-6
• Molecular Formula: C₇H₁₁N
• Molecular Weight: 109.16894
• EINECS: 227-241-6
• Mol File: 5732-87-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 202.7 °C at 760 mmHg
• Flash Point: 82.8 °C
• Appearance: /
• Density: 0.912 g/cm³
• Vapor Pressure: 0.289mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: cyclopentaneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentaneacetonitrile(5732-87-6)
• EPA Substance Registry System: cyclopentaneacetonitrile(5732-87-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5732-87-6(Hazardous Substances Data)

Usage

General Description

Cyclopentaneacetonitrile, also known as 3-cyclopentanecarbonitrile, is a chemical compound with the molecular formula C7H9N. It is a colorless liquid with a slightly sweet odor, commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Cyclopentaneacetonitrile is known to be a versatile intermediate in organic synthesis, as it can undergo various chemical reactions to produce a wide range of derivatives. Its applications include the manufacture of drugs such as gabapentin and pregabalin, as well as the production of insecticides and fungicides. Additionally, it has found use in the creation of fragrances and flavorings. Cyclopentaneacetonitrile is also known for its role as a reagent in organic chemistry reactions, due to its stability and reactivity.

InChI:InChI=1/C7H11N/c8-6-5-7-3-1-2-4-7/h7H,1-5H2

Upstream product

• 13988-39-1 chloromethylcyclopentane 
• 1528-30-9 methylenecyclopentane 
• 150464-47-4 copper(I) cyanide 
• 5732-88-7 cyclopentylideneacetonitrile 
• 142-29-0 cyclopentene 
• 75-05-8 acetonitrile 
• 3814-30-0 cyclopentylmethyl bromide 
• 143-33-9 sodium cyanide 
• 1123-00-8 2-cyclopentylacetic acid 
• 933-04-0 2-cyclopentylacetamide 
• 120-92-3 cyclopentanone 
• 105-34-0 methyl 2-cyanoacetate 
• 183657-62-7 2-Cyclopentyl-1-nitro-ethanone oxime 
• 104413-32-3 7-bromo-2-heptenenitrile 

Downstream Products

• 1122-98-1 1-cyclopentyl-propan-2-one 
• 5763-55-3 2-cyclopentylethan-1-amine 
• 61788-30-5 ethyl α-cyanocyclopentaneacetate 
• 933-04-0 2-cyclopentylacetamide 
• 1202379-57-4 α-cyclopentyl-3,5-dimethoxy-β-oxobenzenepropanenitrile 
• 861081-64-3 N-(2-cyclopentyl-ethyl)-benzamide 
• 102-45-4 cyclopentamine 

Relevant articles and documents

Formal reductive addition of acetonitrile to aldehydes and ketones

An efficient and highly productive rhodium-catalyzed method for the synthesis of nitriles employing aldehydes or ketones, methyl cyanoacetate, water and carbon monoxide as starting materials has been developed. Simple rhodium chloride without any ligands can be used. The fine tuning of the substrate can lead to the activity higher than 5000 TON.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of protein kinase inhibitors, more specifically the present invention is directed to inhibitors of the members of the Tec or Src protein kinase families. The present invention also relates to the processes of preparation of these compounds, their intermediates, to the pharmaceutical compositions comprising them, and to their use in the treatment of proliferative, inflammatory, autoimmune, or infectious disease, disorders, or conditions in which protein kinase activity is implicated. More particularly, the present invention relates to a compound of Formula I.

Kinase inhibitors as therapeutic agents

The present application is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.