57338-20-2

Basic information

• Product Name: 2-Propenoic acid, 2-cyano-3-[(4-nitrophenyl)amino]-, ethyl ester, (Z)-
• CAS NO: 57338-20-2
• Molecular Formula: C12H11N3O4
• Molecular Weight: 261.237
• Mol File: 57338-20-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-cyano-3-[(4-nitrophenyl)amino]-, ethyl ester, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-cyano-3-[(4-nitrophenyl)amino]-, ethyl ester, (Z)-(57338-20-2)
• EPA Substance Registry System: 2-Propenoic acid, 2-cyano-3-[(4-nitrophenyl)amino]-, ethyl ester, (Z)-(57338-20-2)

Safety Data

• Hazardous Substances Data: 57338-20-2(Hazardous Substances Data)

Upstream product

• 94-05-3 2-cyano-3-ethoxyacrylic acid ethyl ester 
• 77755-81-8 N-(2-morpholinoethyl)-4-nitroaniline 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 214470-35-6 6-nitro-4-oxo-1,4-dihydro-quinoline-3-carbonitrile 
• 214485-09-3 4-[(3-chloro-4-fluorophenyl)amino]-6-nitro-quinoline-3-carbonitrile 
• 214485-08-2 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-quinoline-3-carbonitrile 
• 214470-37-8 4-chloro-6-nitro-3-quinolinecarbonitrile 
• 915360-45-1 6-(3-amino-benzylamino)-4-(3-chloro-4-fluoro-phenylamino)-quinoline-3-carbonitrile 

Relevant articles and documents

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles

We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tpl2) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identifi

USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula (1); wherein R1, R2, R3, R4, X, Y, and n are defined hereinbefore, or a pharmaceutically acceptable salt thereof.

Method of treating or inhibiting colonic polyps

This invention provides a method of treating or inhibiting colonic polyps which comprises providing a compound of formula 1 wherein:R1, R2, R3, R4, X, Y, and n are as defined hereinbefore, or a pharmaceutically acceptable salt thereof.