5734-63-4

Basic information

• Product Name: 2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine
• Synonyms: 4-Methyl-6-(trifluoromethyl)pyrimidine-2-amine;Albb-005393;4-methyl-6-(trifluoromethyl)-2-pyrimidinamine(SALTDATA: FREE);2-AMino-4-trifluoroMethyl-6-Methyl pyriMidine
• CAS NO: 5734-63-4
• Molecular Formula: C₆H₆F₃N₃
• Molecular Weight: 177.13
• Product Categories: Amines;Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 5734-63-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 268.3°C at 760 mmHg
• Flash Point: 116°C
• Appearance: /
• Density: 1.384g/cm³
• Vapor Pressure: 0.00776mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine(5734-63-4)
• EPA Substance Registry System: 2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine(5734-63-4)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5734-63-4(Hazardous Substances Data)

Usage

General Description

2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine is a chemical compound with the molecular formula C6H6F3N3. It belongs to the family of pyrimidines, which are aromatic heterocyclic organic compounds similar to the molecule pyridine. Pyrimidines are also key components of nucleic acids like DNA and RNA. The physical characteristics or properties of this compound like melting point, boiling point, density, and its various spectroscopy values are valuable information for chemists and researchers. It does not naturally occur and is synthesized in laboratories for various research and industrial purposes. The possible applications in related chemical reactions and processes can range from pharmaceuticals to agrochemicals. However, specific safety measures and appropriate handling should be observed due to probable risks associated with exposure or ingestion.

InChI:InChI=1/C6H6F3N3/c1-3-2-4(6(7,8)9)12-5(10)11-3/h2H,1H3,(H2,10,11,12)

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 420-04-2 CYANAMID 
• 594-14-9 guanidinium sulfate 
• 877178-95-5 2-amino-6-methyl-4-(trifluoromethyl)pyrimidine 1-oxide 
• 1020540-97-9 4-trifluoromethyl-6-methyl-2-acetylaminopyrimidine 
• 113-00-8 guanidine nitrate 
• 50-01-1 guanidine hydrochloride 
• 135351-20-1 (3E)-1,1,1-trifluoro-4-methoxy-pent-3-en-2-one 

Downstream Products

• 241164-09-0 2-chloro-6-methyl-4-(trifluoromethyl)pyrimidine 
• 1097721-66-8 2-(2,6-dibromophenyl)-3-(4-methyl-6-trifluoromethylpyrimidin-2-yl)thiazolidin-4-one 

Relevant articles and documents

One-pot synthesis of N2-aminoprotected 6-substituted and cycloalka[d] 4-trifluoromethyl-2-acetylaminopyrimidines

(Chemical Equation Presented) The one-pot synthesis of a novel series of amino-protected 6-alkyl-, 6-aryl-, 6-heteroaryl- and 5,6-fused-cycloalkane 4-trifluoromethyl-2-acetylaminopyrimidines, where alkyl = Me; aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh, 4-OCH3Ph, 4-NO 2Ph, 4,4′-biphenyl, 1-naphthyl; heteroaryl = 2-thienyl, 2-furyl and cycloalkyl = c-C6H4, c-C7H5 from the reaction of substituted 4-methoxy-1,1,1-trifluoroalk-3-en-2-ones with 1-acetylguanidine in acetonitrile or propan-2-ol as solvent, is reported. The acetylamino group of 2-acetylaminopyrimidines was hydrolyzed under three different conditions to afford the corresponding free 2-aminopyrimidines.

One-pot synthesis of fluorinated 2-amino-pyrimidine-N-oxides. Competing pathways in the four-atom side-chain rearrangements of 1,2,4-oxadiazoles

Trifluoromethylated 2-amino-pyrimidine N-oxides have been synthesized by reaction of the 3-amino-5-methyl-1,2,4-oxadiazole with trifluoromethyl-β- diketones in the presence of perchloric acid, followed by hydrolysis. In this ring-to-ring transformation an initial formation of (unisolated) 1,2,4-oxadiazole-pyrimidinium salts, and subsequent ring-opening at the oxadiazole moiety occurs. Isolation of 2-(hydroxyamino)-pyrimidine from the reaction mixture evidenced the presence of a competing pathway where the N(4) nitrogen of the oxadiazole is involved in the formation of a regioisomeric pyrimidinium salt. The effect of the trifluoromethyl group on the product distribution is discussed. By X-ray analysis, the crystal structure of two different N-oxide regioisomers has been unambiguously ascertained.

Haloacetylated Enol Ethers. 8 [12]. Reaction of β-Alkoxyvinyl Trihalomethyl Ketones with Guanidine Hydrochloride. Synthesis of 4-Trihalomethyl-2-Aminopyrimidines

In this work the results of the reaction of β-alkoxyvinyl trihalomethyl ketones 1, 2a-e, with guanidine hydrochloride are reported. Depending on the ketone 1 or 2 and the conditions under which the reactions were carried out, 4-trihalomethyl-2-amino pyrimidines, β-alkoxyvinyl carboxylic acids, or β-acetal carboxylic esters were obtained.