57378-70-8

Basic information

• Product Name: biotin
• Synonyms: 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-;5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoic acid
• CAS NO: 57378-70-8
• Molecular Formula: C₁₀H₁₆N₂O₃S
• Molecular Weight: 244.31
• Mol File: 57378-70-8.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 573.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.267±0.06 g/cm3(Predicted)
• PKA: 4.74±0.10(Predicted)
• CAS DataBase Reference: biotin(CAS DataBase Reference)
• NIST Chemistry Reference: biotin(57378-70-8)
• EPA Substance Registry System: biotin(57378-70-8)

Safety Data

• Hazardous Substances Data: 57378-70-8(Hazardous Substances Data)

Upstream product

• 412041-83-9 3-chloro-2-(4-methoxy-butyl)-tetrahydro-thiophene-3,4-dicarboxylic acid diethyl ester 
• 3304-81-2 5-(2-oxo-2,3-dihydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanoic acid 
• 533-48-2 desthiobiotin 
• 31860-26-1 (3AS,4S,6AR)-1,3-dibenzyl-4-(4-carboxybutyl)-tetrahydro-thieno[3,4-d]imidazol-2(3H)-one 
• 7440-44-0 pyrographite 
• 85718-04-3 biotin N-hydroxysuccinimide ester 
• 78757-37-6 (+/-)-5-(3t-acetylamino-4c-benzoylamino-tetrahydro-[2r]thienyl)-valeric acid methyl ester 
• 75-44-5 phosgene 
• 78757-37-6 (+/-)-5-(3c-acetylamino-4t-benzoylamino-tetrahydro-[2r]thienyl)-valeric acid methyl ester 
• 3737-34-6 (+/-)-5-(3c,4t-diamino-tetrahydro-[2r]thienyl)-valeric acid 
• 59851-13-7 5-oxo-4,5,6,7,8,9-hexahydro-thieno[3,2-b]azocine-3-carboxylic acid hydrazide 
• 59851-12-6 5-oxo-4,5,6,7,8,9-hexahydro-thieno[3,2-b]azocine-3-carboxylic acid methyl ester 
• 59851-08-0 5-(3-amino-4-methoxycarbonyl-thiophen-2-yl)-pentanoic acid 
• 101699-34-7 (+/-)-5-(2-oxo-1-phenylcarbamoyl-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl)-valeric acid anilide 

Downstream Products

• 58-85-5 biotin 
• 58-85-5 vitamin H 
• 608-16-2 (+/-)-biotin methyl ester 
• 135137-85-8 1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-amino-1-tert-butyldimethylsilylhexan-1-ol 
• 135137-86-9 1-N-(4,4'-Dimethoxytrityl)-biotinyl-6-amino-hexan-1-ol 
• 875237-68-6 5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid methyl ester 
• 133643-39-7 5-((3aS,6R,6aR)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoic acid (3-phenyl-propyl)-amide 

Relevant articles and documents

Preparation method for preparing d-biotin by removing N-benzyl by Lewis acid

The invention provides a preparation method for preparing d-biotin by removing N-benzyl by Lewis acid, which comprises the following steps: removing dibenzyl from a dibenzyl biotin solution and Lewisacid in an anhydrous organic solvent under the protection of inert gas by one-step reaction to obtain d-biotin with the total yield of 90% or above and the content of 99% or above, wherein the productmeets the European Pharmacopoeia EP10.0 standard.

A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin

A concise and efficient TEA-mediated desymmetrization of meso-thioanhydride 6 with 5-ethoxy-5-oxopentylzinc bromine has been developed, which affords a convenient strategy for the stereospecific total synthesis of (±)-biotin 1.

Synthesis of 99mTc-IDA-biotin and 99mTc-DTPA-bis-biotin

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