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2-Imidazol-1-yl-ethylamine dihydrochloride, with the molecular formula C6H14Cl2N4, is a dihydrochloride salt derivative of 2-imidazol-1-yl-ethylamine, which is a derivative of histamine. This chemical compound is recognized for its potential applications in various fields, particularly in the pharmaceutical industry, where it serves as a precursor in the synthesis of drugs targeting the central nervous system and cardiovascular system. Its role as a research tool in studies related to histamine receptors and their involvement in physiological and pathological processes further underscores its importance in scientific research and drug development.

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  • 5739-10-6 Structure
  • Basic information

    1. Product Name: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE
    2. Synonyms: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE;1H-Imidazole-1-ethanamine;N-(2-Aminoethyl)imidazole;[2-(1H-imidazol-1-yl)ethyl]amine hydrochloride;2-(1H-Imidazol-1-yl)ethanamine;2-(1H-imidazol-1-yl)ethanamine(SALTDATA: 2HCl);2-(1H-iMidazol-1-yl)ethan-1-aMine dihydrochloride;2-Imidazol-1-yl-ethylamine1500
    3. CAS NO:5739-10-6
    4. Molecular Formula: C5H9N3
    5. Molecular Weight: 111.15
    6. EINECS: N/A
    7. Product Categories: Imidazol&Benzimidazole
    8. Mol File: 5739-10-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 283℃
    3. Flash Point: 125℃
    4. Appearance: /
    5. Density: 1.15
    6. Vapor Pressure: 0.003mmHg at 25°C
    7. Refractive Index: 1.577
    8. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    9. Solubility: N/A
    10. PKA: 7.51±0.10(Predicted)
    11. CAS DataBase Reference: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE(5739-10-6)
    13. EPA Substance Registry System: 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE(5739-10-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5739-10-6(Hazardous Substances Data)

5739-10-6 Usage

Uses

Used in Pharmaceutical Industry:
2-Imidazol-1-yl-ethylamine dihydrochloride is used as a precursor in the synthesis of various drugs, particularly those targeting the central nervous system and cardiovascular system. Its structural similarity to histamine allows it to be a valuable component in the development of medications that can modulate histamine receptor activity, which is crucial for treating a range of conditions related to these systems.
Used as a Research Tool:
In the field of scientific research, 2-Imidazol-1-yl-ethylamine dihydrochloride is utilized as a research tool to study histamine receptors and their role in various physiological and pathological processes. Understanding the interaction of 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE with histamine receptors can provide insights into the development of new therapeutic agents and the treatment of diseases influenced by these receptors.
Used in Antifungal and Antimicrobial Applications:
2-Imidazol-1-yl-ethylamine dihydrochloride has been investigated for its potential antifungal and antimicrobial properties. Its ability to inhibit the growth of certain fungi and bacteria makes it a candidate for use in the development of new antimicrobial agents, which could be particularly beneficial in the context of increasing antibiotic resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 5739-10-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,3 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 5739-10:
(6*5)+(5*7)+(4*3)+(3*9)+(2*1)+(1*0)=106
106 % 10 = 6
So 5739-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H9N3/c6-1-3-8-4-2-7-5-8/h2,4-5H,1,3,6H2

5739-10-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Imidazol-1-yl-ethylamine

1.2 Other means of identification

Product number -
Other names 2-IMIDAZOL-1-YL-ETHYLAMINE DIHYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5739-10-6 SDS

5739-10-6Relevant articles and documents

Rhein specific group modified organic compound, aryl metal complex, preparation method and application thereof

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Paragraph 0102; 0105-0108, (2018/10/11)

The invention discloses a rhein specific group modified organic compound, an aryl metal complex, a preparation method and application thereof. Compared with rhein molecules, the organic compound and metal complex have better antitumor and antibacterial activity, and the metal complex also can induce nucleic acid configuration transformation. Specifically, the aryl metal dimer and the above-mentioned metal complex both have good FTO (fat mass and obesity associated) inhibitory activity, and are good FTO inhibitors. The invention also discloses a synthesis method of the organic compound and themetal complex thereof, and the method has the characteristics of simple technological process, easy operation, and high yield. Finally, the invention discloses application of the rhein group-containing organic compound, the metal complex and aromatic metal dimer thereof in preparation of FTO inhibitor drugs, FTO inhibitor drug components, weight-reducing drugs, weight-reducing drug components, anticancer drugs, anticancer drug components, antibacterial drugs and antibacterial drug components.

CINNAMIC ACID AMIDE DERIVATIVE

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Paragraph 0028; 0057, (2015/11/24)

The present invention provides a cinnamic acid amide derivative having an excellent analgesic action. The cinnamic acid amide derivative of the present invention is a compound showing excellent analgesic actions to not only a nociceptive pain model animal but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains.

Synthesis and characterization of N-substitutional ethylenediamine derivatives

Yao, Ri-Sheng,Jiang, Lai-En,Wu, Sheng-Hua,Deng, Sheng-Song,Yang, Yang

, p. 3792 - 3794 (2012/01/05)

N-Substituted and N,N-disubstituted ethylenediamine derivatives were prepared rapidly in aqueous conditions from 30 to 76 % yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The steps involved Michael addition, hydrazinolysis and Curtius rearrangements. The highlight of this method lies on its convenience and economy in accessing these intermediates.

Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase

Bergstrom, Carl P.,Sloan, Charles P.,Lau, Wai-Yu,Smith, David W.,Zheng, Ming,Hansel, Steven B.,Polson, Craig T.,Corsa, Jason A.,Barten, Donna M.,Felsenstein, Kevin M.,Roberts, Susan B.

, p. 464 - 468 (2008/12/21)

The synthesis and γ-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Aβ in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.

CHEMICAL COMPOUNDS

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Page/Page column 154, (2010/10/20)

The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.

The first potent inhibitors for human glutaminyl cyclase: Synthesis and structure-activity relationship

Buchholz, Mirko,Heiser, Ulrich,Schilling, Stephan,Niestroj, André J.,Zunkel, Katrin,Demuth, Hans-Ulrich

, p. 664 - 677 (2007/10/03)

The first effective inhibitors for human glutaminyl cyclase (QC) are described. The structures are developed by applying a ligand-based optimization approach starting from imidazole. Screening of derivatives of that heterocycle led to compounds of the imidazol-1-yl-alkyl thiourea type as a lead scaffold. A library of thiourea derivatives was synthesized, resulting in an inhibitory improvement by 2 orders of magnitude, leading to 1-(3-(1H-imidazol-1-yl)propyl)- 3-(3,4-dimethoxyphenyl)thiourea as a potent inhibitor. Systematic exploitation of the scaffold revealed a strong impact on the inhibitory efficacy and resulted in the development of imidazole-propyl-thioamides as another new class of potent inhibitors. A flexible alignment of the most potent compounds of the thioamide and thiourea class and a QC substrate revealed a good match of characteristic features of the molecules, which suggests a similar binding mode of both inhibitors and the substrate to the active site of QC.

ORGANIC COMPOUNDS

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Page/Page column 41, (2008/06/13)

Compounds of Formula (I); in free or salt form, wherein Ra, Rb, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Chemokine receptor binding heterocyclic compounds with enhanced efficacy

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Page/Page column 17-19, (2010/02/03)

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

Epoxysuccinamide derivative or salt thereof

-

, (2008/06/13)

PCT No. PCT/JP98/01778 Sec. 371 Date Dec. 17, 1998 Sec. 102(e) Date Dec. 17, 1998 PCT Filed Apr. 17, 1998 PCT Pub. No. WO98/47887 PCT Pub. Date Oct. 29, 1998The invention relates an epoxysuccinamide derivative represented by a formula (I): wherein R1 represents a hydrogen atom, an alkyl or aminoalkyl group, R2 represents an aminoalkyl group which May be substituted, an aryl group which may be substituted, a heterocyclic group which may be substituted, an aralkyl group which may be substituted, or an alkyl group substituted by a heterocyclic ring which may be substituted, or R1 and R2 may form a nitrogen-containing heterocyclic ring, which may be substituted, together with the adjacent nitrogen atoms, and R3 and R4 are the same or different from each other and independently represent a hydrogen atom, or an alkyl or aralkyl group, or a salt thereof, a preparation process thereof, and a medicine comprising such a derivative or salt as an active ingredient. This compound has a specific inhibitory activity for cathepsin L and family enzymes thereof, and is useful as an agent for preventing and treating metabolic osteopathy such as osteoporosis and hypercalcemia.

Method for inhibiting advanced glycosylation of proteins using aminosubstituted imidazoles

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, (2008/06/13)

The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging), Accordingly, a composition is disclosed which comprises 2-aminoimidazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation, The method comprises contacting the target protein with the composition, Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

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