5740-62-5Relevant articles and documents
Investigation on the Photostability of Halometasone and Prednicarbate in the Crystal State and Crystal Structure of Halometasone
Reisch, Johannes,Henkel, Gerald,Ekiz-Guecer, Nurten,Nolte, Gerald
, p. 63 - 68 (2007/10/02)
UV irradiation of halometasone (1) in the crystal state yields three photoproducts: 2-chloro-6α,9-difluoro-11β,17α-dihydroxy-16-α-methyl-3-oxoandrosta-1,4-diene-17β-carbaldehyde (3), 2-chloro-6α,9-difluoro-11β-hydroxy-16α-methylandrosta-1,4-diene-3,17-dione (4) and the dimerization product 2ξ-chloro-2ξ-(2-chloro-6α,9-difluoro-11β,21ξ-trihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl)-6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-4-ene-3,20-dione (5).The structure of 5 is determined by the molecular packing of 1 in the crystal, as shown by an X-ray analysis of 1.Two photoproducts are formed after irradiation of prednicarbate (2): 11β,17-dihydroxy-21-propionyloxypregna-1,4-diene-3,20-dione (6) and 17-(ethoxycarbonyloxy)-11β,21-dihydroxypregna-1,4-diene-3,20-dione (7). Key Words: Prednicarbate / Halometasone / Photochemistry