5754-17-6 Usage
Description
3,6-Dihydroxy-4,5-dimethylpyridazine is an organic compound characterized by its pyridazine ring structure with two hydroxyl groups at the 3rd and 6th positions and two methyl groups at the 4th and 5th positions. It is a valuable research chemical utilized in various laboratory and chemical production processes.
Uses
Used in Research and Development:
3,6-Dihydroxy-4,5-dimethylpyridazine is used as a research chemical for its potential applications in the scientific community. It serves as a key intermediate in the synthesis of more complex organic and pharmaceutical compounds, contributing to the advancement of chemical research.
Used in Organic Synthesis:
In the field of organic chemistry, 3,6-Dihydroxy-4,5-dimethylpyridazine is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a versatile building block for creating novel molecules with specific properties and applications.
Used in Pharmaceutical Intermediates:
3,6-Dihydroxy-4,5-dimethylpyridazine also plays a crucial role in the pharmaceutical industry as an intermediate in the development of new drugs. Its structural features can be exploited to design and synthesize pharmaceutical compounds with desired therapeutic properties, potentially leading to the discovery of new medications for various diseases and conditions.
Synthesis
Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).
Check Digit Verification of cas no
The CAS Registry Mumber 5754-17-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,5 and 4 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5754-17:
(6*5)+(5*7)+(4*5)+(3*4)+(2*1)+(1*7)=106
106 % 10 = 6
So 5754-17-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N2O2/c1-3-4(2)6(10)8-7-5(3)9/h1-2H3,(H,7,9)(H,8,10)
5754-17-6Relevant articles and documents
One-step ring condensation of hydrazine derivatives and cyclic anhydrides
Katrusiak, Anna,Katrusiak, Andrzej
, p. 28 - 36 (2015/03/05)
Hydroxypyridazinone and pyrroledione rings condensation in the reactions of hydrazine hydrate with citraconic, 2,3-dimethylmaleic, succinic and cis-cyclohexanedicarboxylic anhydrides have been conducted in the HCl aqueous solution. The pyridazine-ring condensation yields products unexpected for these conditions. They have been identified by 1H/13C NMR and X-ray diffraction. The course of the reaction toward the five- and six-membered ring condensation strongly depends on methyl and other substituents in the anhydrides and in hydrazine. The obtained products indicate that the ring condensation is controlled by the molecular strains and steric hindrances between the substituents in anhydrides and pyridazinone products. The condensation of cyclic anhydrides with hydrazines has been reduced to one-step reaction and its yield significantly increased.
TRIAZOLIUM SALTS AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS
-
Page/Page column 36, (2011/02/26)
The invention relates to novel compounds of formula I where X, A?, Q1, Q2 Q3, R2, R3, R4, R5, R6, R7, R8 and R9 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-activated recepto
