57546-55-1

Basic information

• Product Name: 2,5-bis(α-hydroxy-α-phenylmethyl)thiophene
• Synonyms: 2,5-bis(α-hydroxy-α-phenylmethyl)thiophene
• CAS NO: 57546-55-1
• Molecular Weight: 296.39
• Mol File: 57546-55-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2,5-bis(α-hydroxy-α-phenylmethyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-bis(α-hydroxy-α-phenylmethyl)thiophene(57546-55-1)
• EPA Substance Registry System: 2,5-bis(α-hydroxy-α-phenylmethyl)thiophene(57546-55-1)

Safety Data

• Hazardous Substances Data: 57546-55-1(Hazardous Substances Data)

Upstream product

• 188290-36-0 thiophene 
• 100-52-7 benzaldehyde 
• 63762-35-6 2,5-dilithiothiophene 

Downstream Products

• 71221-22-2 5,10-bis-4-fluorophenyl-15,20-diphenyl-21,23-dithiaporphyrin 
• 71221-21-1 5,10-bis-4-methoxyphenyl-15,20-diphenyl-21,23-dithiaporphyrin 
• 68231-96-9 2,4,6,8-tetraphenyl-1,5(2,5)-dipyrrola-3(2,5)-tellurophena-7(2,5)-thiophena-cyclooctaphane-1⁽²⁾,4,6,7⁽⁸⁾-tetraene 
• 173322-57-1 2,2'-[thiophene-2,5-diylbis(phenylmethylene)]bis[1H-pyrrole] 
• 57511-57-6 5,10,15,20-tetrakisphenyl-21,23-dithiaporphyrin 
• 72612-47-6 diphenyl(thiophene-2,5-diyl)diketone 

Relevant articles and documents

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Synthesis, characterization, and anti-amoebic screening of core-modified 5,20-bis{2-{[(alkyl)(alkyl′)amino]methyl}ferrocen-1-yl}-10,15-diphenyl-21, 23-dithiaporphyrin (=1,1″-(10,15-diphenyl-21,23-dithiaporphine-5,20-diyl) bis[2-{[(alkyl)(alkyl′)amino]methyl}ferrocene]) derivatives

The synthesis of the first bis-ferrocenyl-substituted core-modified porphyrins, 5,20-bis{2-{[(alkyl)-(alkyl′)amino]methyl}ferrocen-1-yl}-10, 15-diphenyl-21,23-dithiaporphyrin derivatives 6a - 6j, via a multistep route is reported (Schemes 1, 2, and 4). The synthesis was carried out through acid-catalyzed (BF3 ? Et2O) condensation of 1,1″- [thiophene-2,5-diylbis(hydroxymethyl)]bis[2-{[(alkyl)(alkyl′)amino]methyl} ferrocenes] 4a - 4j with 2,2′-[thiophene-2,5-diylbis(phenylmethylene)] bis[1H-pyrrole] (5b) in presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (=4,5-dichloro-3,6-dioxocyclohexa-1,4-diene-1,2-dicarbonitrile; DDQ). Characterization of the compounds was done at each step by means of various spectroscopic techniques. The final compounds were screened for in vitro anti-amoebic activity against the strain HM1:IMSS of E. histolytica (Table 2).

Water soluble, core-modified porphyrins. 3. Synthesis, photophysical properties, and in vitro studies of photosensitization, uptake, and localization with carboxylic acid-substituted derivatives

Water soluble, core-modified porphyrins 1-5 bearing 1-4 carboxylic acid groups were prepared and evaluated in vitro as photosensitizers for photodynamic therapy. The 21,23-core-modified porphyrins 1-5 gave band I absorption maxima with λmax of