57559-52-1

Basic information

• Product Name: 4-Methoxy-2-nitrobenzyl bromide
• Synonyms: 4-Methoxy-2-nitrobenzyl bromide;1-(broMoMethyl)-4-Methoxy-2-nitrobenzene;2-Bromomethyl-5-methoxynitrobenzene;Benzene,1-(broMoMethyl)-4-Methoxy-2-nitro-;-4-methoxy-2-nitrobenzene
• CAS NO: 57559-52-1
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.05802
• Mol File: 57559-52-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 66.5℃ (ethanol )
• Boiling Point: 330.5 °C at 760 mmHg
• Flash Point: 153.7 °C
• Appearance: /
• Density: 1.589±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000319mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Methoxy-2-nitrobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-2-nitrobenzyl bromide(57559-52-1)
• EPA Substance Registry System: 4-Methoxy-2-nitrobenzyl bromide(57559-52-1)

Safety Data

• Hazardous Substances Data: 57559-52-1(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2-nitrobenzyl bromide is a chemical compound with the molecular formula C8H8BrNO4. It is a pale yellow solid that is primarily used as a reagent in organic synthesis. The presence of the methoxy and nitro groups on the benzene ring make this compound useful as a protecting group for alcohols and phenols in organic chemistry. It can also be used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Additionally, 4-Methoxy-2-nitrobenzyl bromide has been reported to have antimicrobial activity, making it potentially useful in the development of new antimicrobial agents. However, it is important to handle this compound with caution due to its reactivity and potential hazards.

InChI:InChI=1/C8H8BrNO3/c1-13-7-3-2-6(5-9)8(4-7)10(11)12/h2-4H,5H2,1H3

Upstream product

• 17484-36-5 4-Methyl-3-nitroanisole 
• 16296-53-0 4-methyl-3-nitrophenyl methanesulfonate 
• 77-78-1 dimethyl sulfate 
• 106-44-5 p-cresol 
• 2042-14-0 4-methyl-5-nitrophenol 
• 22996-23-2 (4-methoxy-2-nitro-phenyl)-methanol 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 

Downstream Products

• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 179104-52-0 4-Methoxy-2-nitrobenzyl methyl ether 
• 223787-44-8 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester 
• 886442-56-4 (4-methoxy-2-nitrobenzyl)triphenylphosphonium bromide 
• 519060-26-5 (Z)-2-(2'-amino-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene 
• 519060-25-4 (Z)-2-(2'-nitro-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene 
• 886443-07-8 (S,Z)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)amino)-3-oxopropyl acetate 
• 22996-23-2 (4-methoxy-2-nitro-phenyl)-methanol 
• 636565-32-7 1-[[(chlorocarbonyl)oxy]methyl]-4-methoxy-2-nitrobenzene 
• 503856-50-6 (2-amino-4-methoxy-benzyl)-phosphonic acid diethyl ester 
• 303040-33-7 (4-methoxy-2-octanoylamino-benzyl)-phosphonic acid diethyl ester 
• 26945-63-1 3-Methoxy-10,11-dihydro-dibenzazepin 
• 223787-47-1 4-(2-(2-bromophenyl)vinyl)-3-nitroanisole 
• 223787-52-8 4-(2-(2-bromophenyl)ethyl)-3-aminoanisole 

Relevant articles and documents

Efficient cosubstrate enzyme pairs for sequence-specific methyltransferase-directed photolabile caging of DNA

Supplemented with synthetic surrogates of their natural cosubstrate S-adenosyl-l-methione (AdoMet), methyltransferases represent a powerful toolbox for the functionalization of biomolecules. By employing novel cosubstrate derivatives in combination with p

Intramolecular Pd-catalyzed reductive amination of enolizable sp3-C-H bonds

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Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects

Novel indazole derivatives were prepared and evaluated for their biological activity and cardiovascular safety profile as human β3-adrenergic receptor (AR) agonists. Although the initial hit compound 5 exhibited significant β3-AR agonistic activity (EC50 = 21 nM), it also exhibited agonistic activity at the α1A-AR (EC50 = 219 nM, selectivity: α1A/β3 = 10-fold). The major metabolite of 5, which was an oxidative product at the indazole 3-methyl moiety, gave a clue to a strategy for improvement of the selectivity for β3-AR agonistic activity versus α1A-AR agonistic activity. Thus, modification of the 3-substituent of the indazole moiety effectively improved the selectivity to develop compound 11 with potent β3-AR agonistic activity (EC50 = 13 nM) and high selectivity (α1A/β3 = >769-fold). Compound 11 was also inactive toward β1 and β2-ARs and showed dose dependent β3-AR mediated relaxation of marmoset urinary bladder smooth muscle, while it did not obviously affect heart rate or blood pressure (iv, 3 mg/kg) in anesthetized rats.