57574-09-1

Basic information

• Product Name: Amineptine
• Synonyms: amineptine;Survector;amineptin;7-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid;Heptanoic acid, 7-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)aMino]-;ONNOFKFOZAJDHT-UHFFFAOYSA-N
• CAS NO: 57574-09-1
• Molecular Formula: C22H27NO2
• Molecular Weight: 337.46
• EINECS: 260-818-0
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 57574-09-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 209 °C
• Boiling Point: 509.9 °C at 760 mmHg
• Flash Point: 262.2 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 3.2E-11mmHg at 25°C
• Refractive Index: 1.596
• PKA: 4.75±0.10(Predicted)
• CAS DataBase Reference: Amineptine(CAS DataBase Reference)
• NIST Chemistry Reference: Amineptine(57574-09-1)
• EPA Substance Registry System: Amineptine(57574-09-1)

Safety Data

• Hazardous Substances Data: 57574-09-1(Hazardous Substances Data)

Usage

Uses

Amineptine is used as an atypical tricyclic antidepressant. Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine.

Definition

ChEBI: A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it w s never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne.

Therapeutic Function

Central stimulant

Enzyme inhibitor

This synthetic dopamine reuptake inhibitor (FW = 338.47 g/mol; CAS 57574-09-1), also known by the trade names Survector?, Maneon?, Directim?, Neolior?, Provector?, and Viaspera? as well as its IUPAC name, 7-[(10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5-yl)amino]heptanoic acid, significantly reduces the effect of 6-hydroxy-dopamine on brain dopamine, increases striatal homovanillic acid concentrations, and shows cross-tolerance. Despite these amphetamine-like properties, amineptine does not alter brain noradrenaline or acetylcholine concentrations, suggesting amineptine is a new type of antidepressant with a brain biochemical profile differing from that of other drugs used in depressive disorders. Amineptine is also a norepinephrine reuptake inhibitor. This agent is also ineffective in reducing amphetamine withdrawal symptoms or craving. Amineptine failed to secure FDA approval and is not a duly authorized drug in the U.S.

InChI:InChI=1/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)