57623-73-1Relevant articles and documents
Synthesis and investigation of anti-inflammatory activity of novel nitric oxide donating hybrid drugs
Chandak, Shailesh L.,Bansode, Amol S.,Murumkar, Prashant R.,Shinde, Monika G.,Bothara, Kailash G.
, p. 3510 - 3517 (2013/07/11)
A small library of nitric oxide donating groups, 4-acetamidophenyl-2-[{2- (nitrooxy)ethyl}(phenyl) amino]benzoate (5a-e) possessing a variety of substituents (-H, -NO2, -CH3, -acetamidophenyl, -SO 2NH2) attached to the fourth position of phenyl ring were synthesized and evaluated for anti-inflammatory, analgesic and ulcerogenic potential. Structure-activity relationship data showed that the 2-phenylaminobenzoic acid skeleton is required for selective COX-2 inhibition. Among all compounds 4-acetamidophenyl-2-[{2-(nitrooxy)ethyl}(phenyl)amino] benzoate (5a) has shown potent anti-inflammatory activity while 4-acetamidophenyl-2-[{4-{(4-acetamidophenoxy)carbonyl} phenyl}{2-(nitrooxy) ethyl}amino]benzoate (5d) has shown potent analgesic activity compared to standard drug diclofenac.
NEW DS DNA BINDING FLUORESCENT DYES
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Page/Page column 17; Sheet 1, (2008/12/05)
The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C