57625-08-8Relevant articles and documents
C?H Activation from Iron(II)-Nitroxido Complexes
Kleinlein, Claudia,Bendelsmith, Andrew J.,Zheng, Shao-Liang,Betley, Theodore A.
, p. 12197 - 12201 (2017)
The reaction of nitroxyl radicals TEMPO (2,2′,6,6′-tetramethylpiperidinyloxyl) and AZADO (2-azaadamantane-N-oxyl) with an iron(I) synthon affords iron(II)-nitroxido complexes (ArL)Fe(κ1-TEMPO) and (ArL)Fe(κ2-N,O
Practical preparation methods for highly active azaadamantane-nitroxyl- radical-type oxidation catalysts
Shibuya, Masatoshi,Sasano, Yusuke,Tomizawa, Masaki,Hamada, Toshimasa,Kozawa, Masami,Nagahama, Noriaki,Iwabuchi, Yoshiharu
, p. 3418 - 3425 (2012/01/03)
We have recently disclosed that a less hindered class of nitroxyl radicals, i.e., 2-azaadamantan-N-oxyl (AZADO), 1-Me-AZADO, and 9-azabicyclo[3.3.1]nonan- N-oxyl (ABNO), exhibit marked catalytic activity for the oxidation of alcohols with the aid of environmentally friendly oxidants, offering a green and sustainable option for current alcohol oxidation. Encouraged by their outstanding catalytic performance, we envisioned the development of scalable routes to these radicals that could be extended to the commercialization of these radicals for benchtop use as well as for industrial use as optional reagents that complement TEMPO, the flagship compound of stable nitroxyl radicals. We herein describe short and reproducible preparation methods for AZADO and 1-Me-AZADO, featuring an efficient construction of the 2-azaadamantane skeleton. 1 Introduction 2 1-Me-AZADO and AZADO: First-Generation Syntheses 3 Second-Generation Synthesis of 1-Me-AZADO 4 Synthetic Venture towards 2-Azaadamantane: Second-Generation Synthesis of AZADO 5 Conclusion. Georg Thieme Verlag Stuttgart.
2-Azaadamantane N-oxyl (AZADO) and 1-Me-AZADO: Highly efficient organocatalysts for oxidation of alcohols
Shibuya, Masatoshi,Tomizawa, Masaki,Suzuki, Iwao,Iwabuchi, Yoshiharu
, p. 8412 - 8413 (2007/10/03)
Development of a stable nitroxyl radical class of catalysts, 2-azaadamantane N-oxyl (AZADO) and 1-Me-AZADO, for highly efficient oxidation of alcohols is described. AZADO and 1-Me-AZADO exhibit superior catalytic proficiency to TEMPO, converting various sterically hindered alcohols to the corresponding carbonyl compounds in excellent yields. Copyright