57651-82-8

Basic information

• Product Name: 1-ALPHA-HYDROXYVITAMIND3
• Synonyms: 25(Oh)d
• CAS NO: 57651-82-8
• Molecular Formula: C₂₇H₄₄O
• Molecular Weight: 400.71
• Mol File: 57651-82-8.mol
• Article Data: 16

Chemical Properties

• Melting Point: 135°C
• Boiling Point: 463.26°C (rough estimate)
• Appearance: /
• Density: 1.0044 (rough estimate)
• Refractive Index: 1.4480 (estimate)
• CAS DataBase Reference: 1-ALPHA-HYDROXYVITAMIND3(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ALPHA-HYDROXYVITAMIND3(57651-82-8)
• EPA Substance Registry System: 1-ALPHA-HYDROXYVITAMIND3(57651-82-8)

Safety Data

• Hazardous Substances Data: 57651-82-8(Hazardous Substances Data)

Usage

Type

Active form of vitamin D3

Function

Regulates calcium and phosphate levels in the body, maintains bone health, supports the immune system, has anti-inflammatory and anti-cancer properties

Synthesis

Synthesized in the kidneys

Uses

Used as a pharmaceutical agent to treat conditions such as osteoporosis, hypoparathyroidism, and renal osteodystrophy

Research

Being researched for potential in the treatment of various other diseases, including autoimmune disorders and certain types of cancer.

Upstream product

• 67-97-0 cholecalciferol 
• 71726-02-8 (S)-3-[(R)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 434-16-2 7-dehydrocholesterol 
• 93601-57-1 1-hydroxymethyl-2-methylenebicyclo<3.1.0>hexane 
• 93490-19-8 (S)-Methoxy-phenyl-acetic acid 2-methylene-bicyclo[3.1.0]hex-1-ylmethyl ester 
• 135446-99-0 (1R,3aR,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-4-((1R,5R)-2-methylene-bicyclo[3.1.0]hex-1-ylethynyl)-octahydro-inden-4-ol 
• 135446-97-8 C₉H₉Li 
• 86805-45-0 C₂₉H₄₆O₄S 
• 86792-03-2 3-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-1,2,3,4,6,7-hexahydro-2λ⁶-benzo[c]thiophen-5-one 
• 86791-92-6 4,4-(ethylenedioxy)-7-diphenylphosphinoylmethylbicyclo<4.2.0>octa-1(6)-ene 
• 86791-85-7 C₁₈H₂₂O₅S 
• 86792-02-1 5-(E)-3,3-ethylenedioxy-vitamin D₃ 
• 88790-49-2 7-[2-(Diphenyl-phosphinoyl)-eth-(E)-ylidene]-8-methylene-1,4-dioxa-spiro[4.5]decane 
• 86791-86-8 C₁₁H₁₅BrO₂ 

Downstream Products

• 67-97-0 vitamin D₃ 
• 50-00-0 formaldehyd 
• 62743-71-9 (5E)-10-Oxo-19-norcholecalciferol 
• 118746-80-8 8α-Hydroxy-9,10-seco-4,6,10(19)-cholestatrien-3-one 
• 87649-55-6 tert-Butyl-{(S)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-methylene-cyclohexyloxy}-dimethyl-silane 
• 71726-02-8 (S)-3-[(R)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-5-ol 
• 67-97-0 (5E)-cholecalciferol 
• 41294-56-8 1α-hydroxycholecalciferol 
• 86307-24-6 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexanol 
• 86307-24-6 (1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS)-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methylene-cyclohexanol 

Relevant articles and documents

SYNTHESIS OF CHOLESTEROL AND VITAMIN D3 FROM PHYTOSTEROLS

The present invention discloses novel method for synthesizing vegan cholesterol and vitamin D3 from inexpensive crude phytosterol.

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway

A structure-activity relationship study to elucidate the structural basis for hedgehog (Hh) signaling inhibition by vitamin D3 (VD3) was performed. Functional and non-functional regions of VD3 and VD2 were obtained through straightforward synthetic means

A new synthetic route to 1,25-dihydroxy-vitamin D3

A synthesis of 1,25-dihydroxy-vitamin D3 using a new acetylenic Ring-A precursor is described. Ring-A synthons 4a or 4b can be prepared in homochiral form by a diastereoselective diazoester cyclization.